Lignan Glycosides from Urena lobata

Four new lignan glycosides; urenalignosides A–D (1–4), along with 12 known ones (5–16) were isolated from Urena lobata. Their structures were determined on the basis of extensive spectroscopic and spectrometric data (1D and 2D NMR; IR; CD; and HRESIMS). Compounds 2–4; 6; 7; 10; and 11 showed inhibit...

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Autores principales: Luo, Yuan, Su, Cong, Ding, Ning, Qi, Bowen, Jia, Fangfang, Xu, Xiping, Liu, Xiao, Wang, Juan, Wang, Xiaohui, Tu, Pengfei, Shi, Shepo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6696325/
https://www.ncbi.nlm.nih.gov/pubmed/31390736
http://dx.doi.org/10.3390/molecules24152850
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author Luo, Yuan
Su, Cong
Ding, Ning
Qi, Bowen
Jia, Fangfang
Xu, Xiping
Liu, Xiao
Wang, Juan
Wang, Xiaohui
Tu, Pengfei
Shi, Shepo
author_facet Luo, Yuan
Su, Cong
Ding, Ning
Qi, Bowen
Jia, Fangfang
Xu, Xiping
Liu, Xiao
Wang, Juan
Wang, Xiaohui
Tu, Pengfei
Shi, Shepo
author_sort Luo, Yuan
collection PubMed
description Four new lignan glycosides; urenalignosides A–D (1–4), along with 12 known ones (5–16) were isolated from Urena lobata. Their structures were determined on the basis of extensive spectroscopic and spectrometric data (1D and 2D NMR; IR; CD; and HRESIMS). Compounds 2–4; 6; 7; 10; and 11 showed inhibition of nitric oxide production in lipopolysaccharide-induced RAW 264.7 macrophage cells with IC(50) values in the range of 25.5–98.4 μM (positive control; quercetin; IC(50) = 7.2 ± 0.2 μM).
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spelling pubmed-66963252019-09-05 Lignan Glycosides from Urena lobata Luo, Yuan Su, Cong Ding, Ning Qi, Bowen Jia, Fangfang Xu, Xiping Liu, Xiao Wang, Juan Wang, Xiaohui Tu, Pengfei Shi, Shepo Molecules Article Four new lignan glycosides; urenalignosides A–D (1–4), along with 12 known ones (5–16) were isolated from Urena lobata. Their structures were determined on the basis of extensive spectroscopic and spectrometric data (1D and 2D NMR; IR; CD; and HRESIMS). Compounds 2–4; 6; 7; 10; and 11 showed inhibition of nitric oxide production in lipopolysaccharide-induced RAW 264.7 macrophage cells with IC(50) values in the range of 25.5–98.4 μM (positive control; quercetin; IC(50) = 7.2 ± 0.2 μM). MDPI 2019-08-06 /pmc/articles/PMC6696325/ /pubmed/31390736 http://dx.doi.org/10.3390/molecules24152850 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Luo, Yuan
Su, Cong
Ding, Ning
Qi, Bowen
Jia, Fangfang
Xu, Xiping
Liu, Xiao
Wang, Juan
Wang, Xiaohui
Tu, Pengfei
Shi, Shepo
Lignan Glycosides from Urena lobata
title Lignan Glycosides from Urena lobata
title_full Lignan Glycosides from Urena lobata
title_fullStr Lignan Glycosides from Urena lobata
title_full_unstemmed Lignan Glycosides from Urena lobata
title_short Lignan Glycosides from Urena lobata
title_sort lignan glycosides from urena lobata
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6696325/
https://www.ncbi.nlm.nih.gov/pubmed/31390736
http://dx.doi.org/10.3390/molecules24152850
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AT xuxiping lignanglycosidesfromurenalobata
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