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Pharmacokinetic and Metabolism Studies of Monomethyl Auristatin F via Liquid Chromatography-Quadrupole-Time-of-Flight Mass Spectrometry

A simple liquid chromatography–quadrupole-time-of-flight–mass spectrometric assay (LC-TOF-MS/MS) has been developed for the evaluation of metabolism and pharmacokinetic (PK) characteristics of monomethyl auristatin F (MMAF) in rat, which is being used as a payload for antibody-drug conjugates. LC-TO...

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Detalles Bibliográficos
Autores principales:	Park, Min-Ho, Lee, Byeong ill, Byeon, Jin-Ju, Shin, Seok-Ho, Choi, Jangmi, Park, Yuri, Shin, Young G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6696338/ https://www.ncbi.nlm.nih.gov/pubmed/31362431 http://dx.doi.org/10.3390/molecules24152754

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