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Association between Peptic Ulcer Disease and Osteoporosis: The Population-Based Longitudinal Cohort Study in Korea

Objectives: The association between peptic ulcer disease (PUD) and osteoporosis remains unclear. We investigated the association between PUD and osteoporosis by classifying individuals based on gender in a prospective study on 10,030 adults in Korea at a 12-year follow-up examination. Design and set...

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Autores principales: Yoon, Phill Hoon, An, Sang Joon, Jeong, Seok-Hoo, Yang, Yun-Jung, Hong, Yeon-pyo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6696469/
https://www.ncbi.nlm.nih.gov/pubmed/31382574
http://dx.doi.org/10.3390/ijerph16152777
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author Yoon, Phill Hoon
An, Sang Joon
Jeong, Seok-Hoo
Yang, Yun-Jung
Hong, Yeon-pyo
author_facet Yoon, Phill Hoon
An, Sang Joon
Jeong, Seok-Hoo
Yang, Yun-Jung
Hong, Yeon-pyo
author_sort Yoon, Phill Hoon
collection PubMed
description Objectives: The association between peptic ulcer disease (PUD) and osteoporosis remains unclear. We investigated the association between PUD and osteoporosis by classifying individuals based on gender in a prospective study on 10,030 adults in Korea at a 12-year follow-up examination. Design and setting: The baseline survey of the Ansung–Ansan cohort studies was conducted from May 2001 to February 2003, and 10,030 participants (5018 from the Ansung study and 5012 from the Ansan study) completed the examination. Primary outcome measures: The risk of developing osteoporosis was higher in both men and women in the PUD group than in the control group. Results: At the 12-year follow-up, osteoporosis had developed in 11.1% (21/189) and 29.9% (56/187) of men and women in the PUD group, respectively. Meanwhile, in the control group, 4.8% (70/1464) and 16.5% (271/1639) of men and women, respectively, were presented with osteoporosis. The incidence rates per 1000 person–years were 20.5% and 68.5% in men and women in the PUD group and 11.2% and 42.3% of men and women in the control group, respectively. The risk of developing osteoporosis was higher in both men and women in the PUD group than in the control group (men: hazard ratio [HR] = 1.72, 95% confidence interval [CI] = 1.02–2.92; women: HR = 1.62, 95% CI = 1.20–2.18). Conclusion: The risk of developing osteoporosis was significantly higher in both men and women in the PUD group than in the control group.
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spelling pubmed-66964692019-09-05 Association between Peptic Ulcer Disease and Osteoporosis: The Population-Based Longitudinal Cohort Study in Korea Yoon, Phill Hoon An, Sang Joon Jeong, Seok-Hoo Yang, Yun-Jung Hong, Yeon-pyo Int J Environ Res Public Health Article Objectives: The association between peptic ulcer disease (PUD) and osteoporosis remains unclear. We investigated the association between PUD and osteoporosis by classifying individuals based on gender in a prospective study on 10,030 adults in Korea at a 12-year follow-up examination. Design and setting: The baseline survey of the Ansung–Ansan cohort studies was conducted from May 2001 to February 2003, and 10,030 participants (5018 from the Ansung study and 5012 from the Ansan study) completed the examination. Primary outcome measures: The risk of developing osteoporosis was higher in both men and women in the PUD group than in the control group. Results: At the 12-year follow-up, osteoporosis had developed in 11.1% (21/189) and 29.9% (56/187) of men and women in the PUD group, respectively. Meanwhile, in the control group, 4.8% (70/1464) and 16.5% (271/1639) of men and women, respectively, were presented with osteoporosis. The incidence rates per 1000 person–years were 20.5% and 68.5% in men and women in the PUD group and 11.2% and 42.3% of men and women in the control group, respectively. The risk of developing osteoporosis was higher in both men and women in the PUD group than in the control group (men: hazard ratio [HR] = 1.72, 95% confidence interval [CI] = 1.02–2.92; women: HR = 1.62, 95% CI = 1.20–2.18). Conclusion: The risk of developing osteoporosis was significantly higher in both men and women in the PUD group than in the control group. MDPI 2019-08-03 2019-08 /pmc/articles/PMC6696469/ /pubmed/31382574 http://dx.doi.org/10.3390/ijerph16152777 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yoon, Phill Hoon
An, Sang Joon
Jeong, Seok-Hoo
Yang, Yun-Jung
Hong, Yeon-pyo
Association between Peptic Ulcer Disease and Osteoporosis: The Population-Based Longitudinal Cohort Study in Korea
title Association between Peptic Ulcer Disease and Osteoporosis: The Population-Based Longitudinal Cohort Study in Korea
title_full Association between Peptic Ulcer Disease and Osteoporosis: The Population-Based Longitudinal Cohort Study in Korea
title_fullStr Association between Peptic Ulcer Disease and Osteoporosis: The Population-Based Longitudinal Cohort Study in Korea
title_full_unstemmed Association between Peptic Ulcer Disease and Osteoporosis: The Population-Based Longitudinal Cohort Study in Korea
title_short Association between Peptic Ulcer Disease and Osteoporosis: The Population-Based Longitudinal Cohort Study in Korea
title_sort association between peptic ulcer disease and osteoporosis: the population-based longitudinal cohort study in korea
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6696469/
https://www.ncbi.nlm.nih.gov/pubmed/31382574
http://dx.doi.org/10.3390/ijerph16152777
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