Cargando…
The interplay of aging, genetics and environmental factors in the pathogenesis of Parkinson’s disease
BACKGROUND: Parkinson’s disease (PD) is characterized by dopaminergic neuronal loss in the substantia nigra pars compacta and intracellular inclusions called Lewy bodies (LB). During the course of disease, misfolded α-synuclein, the major constituent of LB, spreads to different regions of the brain...
Autores principales: | Pang, Shirley Yin-Yu, Ho, Philip Wing-Lok, Liu, Hui-Fang, Leung, Chi-Ting, Li, Lingfei, Chang, Eunice Eun Seo, Ramsden, David Boyer, Ho, Shu-Leong |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6696688/ https://www.ncbi.nlm.nih.gov/pubmed/31428316 http://dx.doi.org/10.1186/s40035-019-0165-9 |
Ejemplares similares
-
LRRK2 mutant knock-in mouse models: therapeutic relevance in Parkinson's disease
por: Chang, Eunice Eun Seo, et al.
Publicado: (2022) -
In vivo overexpression of synaptogyrin‐3 promotes striatal synaptic dopamine uptake in LRRK2(R1441G) mutant mouse model of Parkinson's disease
por: Ho, Philip Wing‐Lok, et al.
Publicado: (2023) -
Combined LRRK2 mutation, aging and chronic low dose oral rotenone as a model of Parkinson’s disease
por: Liu, Hui-Fang, et al.
Publicado: (2017) -
Age-dependent accumulation of oligomeric SNCA/α-synuclein from impaired degradation in mutant LRRK2 knockin mouse model of Parkinson disease: role for therapeutic activation of chaperone-mediated autophagy (CMA)
por: Ho, Philip Wing-Lok, et al.
Publicado: (2019) -
LRRK2, GBA and their interaction in the regulation of autophagy: implications on therapeutics in Parkinson's disease
por: Pang, Shirley Yin-Yu, et al.
Publicado: (2022)