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Gender Difference Response of Male and Female Immunodeficiency Rats Treated with Tissue-specific Biomolecules
Background: The modern immunology is targeted to the detailed study of various immunopathological conditions at the molecular and cellular level, development of new methods for the prevention, diagnostics and treatment of contagious and non-contagious diseases of humans and animals. Methods: In the...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Bentham Science Publishers
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6696827/ https://www.ncbi.nlm.nih.gov/pubmed/30806311 http://dx.doi.org/10.2174/1389201020666190222184814 |
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author | Fedulova, Liliya V. Basov, Alexandr A. Vasilevskaya, Ekaterina R. Dzhimak, Stepan S. |
author_facet | Fedulova, Liliya V. Basov, Alexandr A. Vasilevskaya, Ekaterina R. Dzhimak, Stepan S. |
author_sort | Fedulova, Liliya V. |
collection | PubMed |
description | Background: The modern immunology is targeted to the detailed study of various immunopathological conditions at the molecular and cellular level, development of new methods for the prevention, diagnostics and treatment of contagious and non-contagious diseases of humans and animals. Methods: In the present work we took the rats with model of cyclophosphamide-induced immunodeficiency and studied the features of gender impact of the complex extract of immunocompetent organs (thymus, spleen and mesenteric lymph nodes) Sus scrofa and its separate fraction with molecular weight less than 30 kDa administered to male and female rats. Results and Conclusion: The impact of gender differences and tissue-specific biomolecules (30 kDa fraction) on hematological parameters (leukocytes, erythrocytes, platelets), functional activity of immune system (IL-2, IL-4, IL-6, complement system, IgG, IgM), biochemical parameters of hepatocytes functioning (activity of ALP and LDG), carbohydrate metabolism (glucose) and lipid metabolism (triglycerides). |
format | Online Article Text |
id | pubmed-6696827 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Bentham Science Publishers |
record_format | MEDLINE/PubMed |
spelling | pubmed-66968272019-11-30 Gender Difference Response of Male and Female Immunodeficiency Rats Treated with Tissue-specific Biomolecules Fedulova, Liliya V. Basov, Alexandr A. Vasilevskaya, Ekaterina R. Dzhimak, Stepan S. Curr Pharm Biotechnol Article Background: The modern immunology is targeted to the detailed study of various immunopathological conditions at the molecular and cellular level, development of new methods for the prevention, diagnostics and treatment of contagious and non-contagious diseases of humans and animals. Methods: In the present work we took the rats with model of cyclophosphamide-induced immunodeficiency and studied the features of gender impact of the complex extract of immunocompetent organs (thymus, spleen and mesenteric lymph nodes) Sus scrofa and its separate fraction with molecular weight less than 30 kDa administered to male and female rats. Results and Conclusion: The impact of gender differences and tissue-specific biomolecules (30 kDa fraction) on hematological parameters (leukocytes, erythrocytes, platelets), functional activity of immune system (IL-2, IL-4, IL-6, complement system, IgG, IgM), biochemical parameters of hepatocytes functioning (activity of ALP and LDG), carbohydrate metabolism (glucose) and lipid metabolism (triglycerides). Bentham Science Publishers 2019-12 2019-12 /pmc/articles/PMC6696827/ /pubmed/30806311 http://dx.doi.org/10.2174/1389201020666190222184814 Text en © 2019 Bentham Science Publishers https://creativecommons.org/licenses/by-nc/4.0/legalcode This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) (https://creativecommons.org/licenses/by-nc/4.0/legalcode), which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited. |
spellingShingle | Article Fedulova, Liliya V. Basov, Alexandr A. Vasilevskaya, Ekaterina R. Dzhimak, Stepan S. Gender Difference Response of Male and Female Immunodeficiency Rats Treated with Tissue-specific Biomolecules |
title | Gender Difference Response of Male and Female Immunodeficiency Rats Treated with Tissue-specific Biomolecules |
title_full | Gender Difference Response of Male and Female Immunodeficiency Rats Treated with Tissue-specific Biomolecules |
title_fullStr | Gender Difference Response of Male and Female Immunodeficiency Rats Treated with Tissue-specific Biomolecules |
title_full_unstemmed | Gender Difference Response of Male and Female Immunodeficiency Rats Treated with Tissue-specific Biomolecules |
title_short | Gender Difference Response of Male and Female Immunodeficiency Rats Treated with Tissue-specific Biomolecules |
title_sort | gender difference response of male and female immunodeficiency rats treated with tissue-specific biomolecules |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6696827/ https://www.ncbi.nlm.nih.gov/pubmed/30806311 http://dx.doi.org/10.2174/1389201020666190222184814 |
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