Cargando…
Acupressure to Reduce Treatment-Related Symptoms for Children With Cancer and Recipients of Hematopoietic Stem Cell Transplant: Protocol for a Randomized Controlled Trial
BACKGROUND: We describe the study design and protocol of a pragmatic randomized controlled trial (RCT) Acupressure for Children in Treatment for a Childhood Cancer (ACT-CC). OBJECTIVE: To describe the feasibility and effectiveness of an acupressure intervention to decrease treatment-related symptoms...
Autores principales: | , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6696841/ https://www.ncbi.nlm.nih.gov/pubmed/31453017 http://dx.doi.org/10.1177/2164956119870444 |
_version_ | 1783444339358171136 |
---|---|
author | Lown, E Anne Banerjee, Anu Vittinghoff, Eric Dvorak, Christopher C Hartogensis, Wendy Melton, Alexis Mangurian, Christina Hu, Hiroe Shear, Deborah Adcock, Robyn Morgan, Michael Golden, Carla Hecht, Frederick M |
author_facet | Lown, E Anne Banerjee, Anu Vittinghoff, Eric Dvorak, Christopher C Hartogensis, Wendy Melton, Alexis Mangurian, Christina Hu, Hiroe Shear, Deborah Adcock, Robyn Morgan, Michael Golden, Carla Hecht, Frederick M |
author_sort | Lown, E Anne |
collection | PubMed |
description | BACKGROUND: We describe the study design and protocol of a pragmatic randomized controlled trial (RCT) Acupressure for Children in Treatment for a Childhood Cancer (ACT-CC). OBJECTIVE: To describe the feasibility and effectiveness of an acupressure intervention to decrease treatment-related symptoms in children in treatment for cancer or recipients of a chemotherapy-based hematopoietic stem cell transplant (HSCT). DESIGN: Two-armed RCTs with enrollment of 5 to 30 study days. SETTING: Two pediatric teaching hospitals. PATIENTS: Eighty-five children receiving cancer treatment or a chemotherapy-based HSCT each with 1 parent or caregiver. INTERVENTION: Patients are randomized 1:1 to receive either usual care plus daily professional acupressure and caregiver delivered acupressure versus usual care alone for symptom management. Participants receive up to 20 professional treatments. MAIN OUTCOME: A composite nausea/vomiting measure for the child. SECONDARY OUTCOMES: Child’s nausea, vomiting, pain, fatigue, depression, anxiety, and positive affect. PARENT OUTCOMES: Depression, anxiety, posttraumatic stress symptoms, caregiver self-efficacy, and positive affect. Feasibility of delivering the semistandardized intervention will be described. Linear mixed models will be used to compare outcomes between arms in children and parents, allowing for variability in diagnosis, treatment, and age. DISCUSSION: Trial results could help childhood cancer and HSCT treatment centers decide about the regular inclusion of trained acupressure providers to support symptom management. |
format | Online Article Text |
id | pubmed-6696841 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-66968412019-08-26 Acupressure to Reduce Treatment-Related Symptoms for Children With Cancer and Recipients of Hematopoietic Stem Cell Transplant: Protocol for a Randomized Controlled Trial Lown, E Anne Banerjee, Anu Vittinghoff, Eric Dvorak, Christopher C Hartogensis, Wendy Melton, Alexis Mangurian, Christina Hu, Hiroe Shear, Deborah Adcock, Robyn Morgan, Michael Golden, Carla Hecht, Frederick M Glob Adv Health Med Original Article BACKGROUND: We describe the study design and protocol of a pragmatic randomized controlled trial (RCT) Acupressure for Children in Treatment for a Childhood Cancer (ACT-CC). OBJECTIVE: To describe the feasibility and effectiveness of an acupressure intervention to decrease treatment-related symptoms in children in treatment for cancer or recipients of a chemotherapy-based hematopoietic stem cell transplant (HSCT). DESIGN: Two-armed RCTs with enrollment of 5 to 30 study days. SETTING: Two pediatric teaching hospitals. PATIENTS: Eighty-five children receiving cancer treatment or a chemotherapy-based HSCT each with 1 parent or caregiver. INTERVENTION: Patients are randomized 1:1 to receive either usual care plus daily professional acupressure and caregiver delivered acupressure versus usual care alone for symptom management. Participants receive up to 20 professional treatments. MAIN OUTCOME: A composite nausea/vomiting measure for the child. SECONDARY OUTCOMES: Child’s nausea, vomiting, pain, fatigue, depression, anxiety, and positive affect. PARENT OUTCOMES: Depression, anxiety, posttraumatic stress symptoms, caregiver self-efficacy, and positive affect. Feasibility of delivering the semistandardized intervention will be described. Linear mixed models will be used to compare outcomes between arms in children and parents, allowing for variability in diagnosis, treatment, and age. DISCUSSION: Trial results could help childhood cancer and HSCT treatment centers decide about the regular inclusion of trained acupressure providers to support symptom management. SAGE Publications 2019-08-14 /pmc/articles/PMC6696841/ /pubmed/31453017 http://dx.doi.org/10.1177/2164956119870444 Text en © The Author(s) 2019 http://creativecommons.org/licenses/by-nc/4.0/ Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Original Article Lown, E Anne Banerjee, Anu Vittinghoff, Eric Dvorak, Christopher C Hartogensis, Wendy Melton, Alexis Mangurian, Christina Hu, Hiroe Shear, Deborah Adcock, Robyn Morgan, Michael Golden, Carla Hecht, Frederick M Acupressure to Reduce Treatment-Related Symptoms for Children With Cancer and Recipients of Hematopoietic Stem Cell Transplant: Protocol for a Randomized Controlled Trial |
title | Acupressure to Reduce Treatment-Related Symptoms for Children With Cancer and Recipients of Hematopoietic Stem Cell Transplant: Protocol for a Randomized Controlled Trial |
title_full | Acupressure to Reduce Treatment-Related Symptoms for Children With Cancer and Recipients of Hematopoietic Stem Cell Transplant: Protocol for a Randomized Controlled Trial |
title_fullStr | Acupressure to Reduce Treatment-Related Symptoms for Children With Cancer and Recipients of Hematopoietic Stem Cell Transplant: Protocol for a Randomized Controlled Trial |
title_full_unstemmed | Acupressure to Reduce Treatment-Related Symptoms for Children With Cancer and Recipients of Hematopoietic Stem Cell Transplant: Protocol for a Randomized Controlled Trial |
title_short | Acupressure to Reduce Treatment-Related Symptoms for Children With Cancer and Recipients of Hematopoietic Stem Cell Transplant: Protocol for a Randomized Controlled Trial |
title_sort | acupressure to reduce treatment-related symptoms for children with cancer and recipients of hematopoietic stem cell transplant: protocol for a randomized controlled trial |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6696841/ https://www.ncbi.nlm.nih.gov/pubmed/31453017 http://dx.doi.org/10.1177/2164956119870444 |
work_keys_str_mv | AT lowneanne acupressuretoreducetreatmentrelatedsymptomsforchildrenwithcancerandrecipientsofhematopoieticstemcelltransplantprotocolforarandomizedcontrolledtrial AT banerjeeanu acupressuretoreducetreatmentrelatedsymptomsforchildrenwithcancerandrecipientsofhematopoieticstemcelltransplantprotocolforarandomizedcontrolledtrial AT vittinghofferic acupressuretoreducetreatmentrelatedsymptomsforchildrenwithcancerandrecipientsofhematopoieticstemcelltransplantprotocolforarandomizedcontrolledtrial AT dvorakchristopherc acupressuretoreducetreatmentrelatedsymptomsforchildrenwithcancerandrecipientsofhematopoieticstemcelltransplantprotocolforarandomizedcontrolledtrial AT hartogensiswendy acupressuretoreducetreatmentrelatedsymptomsforchildrenwithcancerandrecipientsofhematopoieticstemcelltransplantprotocolforarandomizedcontrolledtrial AT meltonalexis acupressuretoreducetreatmentrelatedsymptomsforchildrenwithcancerandrecipientsofhematopoieticstemcelltransplantprotocolforarandomizedcontrolledtrial AT mangurianchristina acupressuretoreducetreatmentrelatedsymptomsforchildrenwithcancerandrecipientsofhematopoieticstemcelltransplantprotocolforarandomizedcontrolledtrial AT huhiroe acupressuretoreducetreatmentrelatedsymptomsforchildrenwithcancerandrecipientsofhematopoieticstemcelltransplantprotocolforarandomizedcontrolledtrial AT sheardeborah acupressuretoreducetreatmentrelatedsymptomsforchildrenwithcancerandrecipientsofhematopoieticstemcelltransplantprotocolforarandomizedcontrolledtrial AT adcockrobyn acupressuretoreducetreatmentrelatedsymptomsforchildrenwithcancerandrecipientsofhematopoieticstemcelltransplantprotocolforarandomizedcontrolledtrial AT morganmichael acupressuretoreducetreatmentrelatedsymptomsforchildrenwithcancerandrecipientsofhematopoieticstemcelltransplantprotocolforarandomizedcontrolledtrial AT goldencarla acupressuretoreducetreatmentrelatedsymptomsforchildrenwithcancerandrecipientsofhematopoieticstemcelltransplantprotocolforarandomizedcontrolledtrial AT hechtfrederickm acupressuretoreducetreatmentrelatedsymptomsforchildrenwithcancerandrecipientsofhematopoieticstemcelltransplantprotocolforarandomizedcontrolledtrial |