The Antiviral and Antitumor Effects of Defective Interfering Particles/Genomes and Their Mechanisms

Defective interfering particles (DIPs), derived naturally from viral particles, are not able to replicate on their own. Several studies indicate that DIPs exert antiviral effects via multiple mechanisms. DIPs are able to activate immune responses and suppress virus replication cycles, such as compet...

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Autores principales: Yang, Yicheng, Lyu, Taibiao, Zhou, Runing, He, Xiaoen, Ye, Kaiyan, Xie, Qian, Zhu, Li, Chen, Tingting, Shen, Chu, Wu, Qinghua, Zhang, Bao, Zhao, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6696905/
https://www.ncbi.nlm.nih.gov/pubmed/31447826
http://dx.doi.org/10.3389/fmicb.2019.01852
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author Yang, Yicheng
Lyu, Taibiao
Zhou, Runing
He, Xiaoen
Ye, Kaiyan
Xie, Qian
Zhu, Li
Chen, Tingting
Shen, Chu
Wu, Qinghua
Zhang, Bao
Zhao, Wei
author_facet Yang, Yicheng
Lyu, Taibiao
Zhou, Runing
He, Xiaoen
Ye, Kaiyan
Xie, Qian
Zhu, Li
Chen, Tingting
Shen, Chu
Wu, Qinghua
Zhang, Bao
Zhao, Wei
author_sort Yang, Yicheng
collection PubMed
description Defective interfering particles (DIPs), derived naturally from viral particles, are not able to replicate on their own. Several studies indicate that DIPs exert antiviral effects via multiple mechanisms. DIPs are able to activate immune responses and suppress virus replication cycles, such as competing for viral replication products, impeding the packaging, release and invasion of viruses. Other studies show that DIPs can be used as a vaccine against viral infection. Moreover, DIPs/DI genomes display antitumor effects by inducing tumor cell apoptosis and promoting dendritic cell maturation. With genetic modified techniques, it is possible to improve its safety against both viruses and tumors. In this review, a comprehensive discussion on the effects exerted by DIPs is provided. We further highlight the clinical significance of DIPs and propose that DIPs can open up a new platform for antiviral and antitumor therapies.
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spelling pubmed-66969052019-08-23 The Antiviral and Antitumor Effects of Defective Interfering Particles/Genomes and Their Mechanisms Yang, Yicheng Lyu, Taibiao Zhou, Runing He, Xiaoen Ye, Kaiyan Xie, Qian Zhu, Li Chen, Tingting Shen, Chu Wu, Qinghua Zhang, Bao Zhao, Wei Front Microbiol Microbiology Defective interfering particles (DIPs), derived naturally from viral particles, are not able to replicate on their own. Several studies indicate that DIPs exert antiviral effects via multiple mechanisms. DIPs are able to activate immune responses and suppress virus replication cycles, such as competing for viral replication products, impeding the packaging, release and invasion of viruses. Other studies show that DIPs can be used as a vaccine against viral infection. Moreover, DIPs/DI genomes display antitumor effects by inducing tumor cell apoptosis and promoting dendritic cell maturation. With genetic modified techniques, it is possible to improve its safety against both viruses and tumors. In this review, a comprehensive discussion on the effects exerted by DIPs is provided. We further highlight the clinical significance of DIPs and propose that DIPs can open up a new platform for antiviral and antitumor therapies. Frontiers Media S.A. 2019-08-09 /pmc/articles/PMC6696905/ /pubmed/31447826 http://dx.doi.org/10.3389/fmicb.2019.01852 Text en Copyright © 2019 Yang, Lyu, Zhou, He, Ye, Xie, Zhu, Chen, Shen, Wu, Zhang and Zhao. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Yang, Yicheng
Lyu, Taibiao
Zhou, Runing
He, Xiaoen
Ye, Kaiyan
Xie, Qian
Zhu, Li
Chen, Tingting
Shen, Chu
Wu, Qinghua
Zhang, Bao
Zhao, Wei
The Antiviral and Antitumor Effects of Defective Interfering Particles/Genomes and Their Mechanisms
title The Antiviral and Antitumor Effects of Defective Interfering Particles/Genomes and Their Mechanisms
title_full The Antiviral and Antitumor Effects of Defective Interfering Particles/Genomes and Their Mechanisms
title_fullStr The Antiviral and Antitumor Effects of Defective Interfering Particles/Genomes and Their Mechanisms
title_full_unstemmed The Antiviral and Antitumor Effects of Defective Interfering Particles/Genomes and Their Mechanisms
title_short The Antiviral and Antitumor Effects of Defective Interfering Particles/Genomes and Their Mechanisms
title_sort antiviral and antitumor effects of defective interfering particles/genomes and their mechanisms
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6696905/
https://www.ncbi.nlm.nih.gov/pubmed/31447826
http://dx.doi.org/10.3389/fmicb.2019.01852
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