MITOL deletion in the brain impairs mitochondrial structure and ER tethering leading to oxidative stress

Mitochondrial abnormalities are associated with developmental disorders, although a causal relationship remains largely unknown. Here, we report that increased oxidative stress in neurons by deletion of mitochondrial ubiquitin ligase MITOL causes a potential neuroinflammation including aberrant astr...

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Detalles Bibliográficos
Autores principales: Nagashima, Shun, Takeda, Keisuke, Ohno, Nobuhiko, Ishido, Satoshi, Aoki, Motohide, Saitoh, Yurika, Takada, Takumi, Tokuyama, Takeshi, Sugiura, Ayumu, Fukuda, Toshifumi, Matsushita, Nobuko, Inatome, Ryoko, Yanagi, Shigeru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6696985/
https://www.ncbi.nlm.nih.gov/pubmed/31416892
http://dx.doi.org/10.26508/lsa.201900308

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