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Differentially Expressed Genes Associated With Prognosis in Locally Advanced Lymph Node-Negative Prostate Cancer
Older age is one of the main risk factors for cancer development. The incidence of prostate cancer, as a multifactorial disease, also depends upon demographic factors, race, and genetic predisposition. Prostate cancer most frequently occurs in men over 60 years of age, indicating a clear association...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6697060/ https://www.ncbi.nlm.nih.gov/pubmed/31447885 http://dx.doi.org/10.3389/fgene.2019.00730 |
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author | Pudova, Elena A. Lukyanova, Elena N. Nyushko, Kirill M. Mikhaylenko, Dmitry S. Zaretsky, Andrew R. Snezhkina, Anastasiya V. Savvateeva, Maria V. Kobelyatskaya, Anastasiya A. Melnikova, Nataliya V. Volchenko, Nadezhda N. Efremov, Gennady D. Klimina, Kseniya M. Belova, Anastasiya A. Kiseleva, Marina V. Kaprin, Andrey D. Alekseev, Boris Y. Krasnov, George S. Kudryavtseva, Anna V. |
author_facet | Pudova, Elena A. Lukyanova, Elena N. Nyushko, Kirill M. Mikhaylenko, Dmitry S. Zaretsky, Andrew R. Snezhkina, Anastasiya V. Savvateeva, Maria V. Kobelyatskaya, Anastasiya A. Melnikova, Nataliya V. Volchenko, Nadezhda N. Efremov, Gennady D. Klimina, Kseniya M. Belova, Anastasiya A. Kiseleva, Marina V. Kaprin, Andrey D. Alekseev, Boris Y. Krasnov, George S. Kudryavtseva, Anna V. |
author_sort | Pudova, Elena A. |
collection | PubMed |
description | Older age is one of the main risk factors for cancer development. The incidence of prostate cancer, as a multifactorial disease, also depends upon demographic factors, race, and genetic predisposition. Prostate cancer most frequently occurs in men over 60 years of age, indicating a clear association between older age and disease onset. Carcinogenesis is followed by the deregulation of many genes, and some of these changes could serve as biomarkers for diagnosis, prognosis, prediction of drug therapy efficacy, as well as possible therapeutic targets. We have performed a bioinformatic analysis of a The Cancer Genome Atlas (TCGA) data and RNA-Seq profiling of a Russian patient cohort to reveal prognostic markers of locally advanced lymph node-negative prostate cancer (lymph node-negative LAPC). We also aimed to identify markers of the most common molecular subtype of prostate cancer carrying a fusion transcript TMPRSS2-ERG. We have found several genes that were differently expressed between the favorable and unfavorable prognosis groups and involved in the enriched KEGG pathways based on the TCGA (B4GALNT4, PTK6, and CHAT) and Russian patient cohort data (AKR1C1 and AKR1C3). Additionally, we revealed such genes for the TMPRSS2-ERG prostate cancer molecular subtype (B4GALNT4, ASRGL1, MYBPC1, RGS11, SLC6A14, GALNT13, and ST6GALNAC1). Obtained results contribute to a better understanding of the molecular mechanisms behind prostate cancer progression and could be used for further development of the LAPC prognosis marker panel. |
format | Online Article Text |
id | pubmed-6697060 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-66970602019-08-23 Differentially Expressed Genes Associated With Prognosis in Locally Advanced Lymph Node-Negative Prostate Cancer Pudova, Elena A. Lukyanova, Elena N. Nyushko, Kirill M. Mikhaylenko, Dmitry S. Zaretsky, Andrew R. Snezhkina, Anastasiya V. Savvateeva, Maria V. Kobelyatskaya, Anastasiya A. Melnikova, Nataliya V. Volchenko, Nadezhda N. Efremov, Gennady D. Klimina, Kseniya M. Belova, Anastasiya A. Kiseleva, Marina V. Kaprin, Andrey D. Alekseev, Boris Y. Krasnov, George S. Kudryavtseva, Anna V. Front Genet Genetics Older age is one of the main risk factors for cancer development. The incidence of prostate cancer, as a multifactorial disease, also depends upon demographic factors, race, and genetic predisposition. Prostate cancer most frequently occurs in men over 60 years of age, indicating a clear association between older age and disease onset. Carcinogenesis is followed by the deregulation of many genes, and some of these changes could serve as biomarkers for diagnosis, prognosis, prediction of drug therapy efficacy, as well as possible therapeutic targets. We have performed a bioinformatic analysis of a The Cancer Genome Atlas (TCGA) data and RNA-Seq profiling of a Russian patient cohort to reveal prognostic markers of locally advanced lymph node-negative prostate cancer (lymph node-negative LAPC). We also aimed to identify markers of the most common molecular subtype of prostate cancer carrying a fusion transcript TMPRSS2-ERG. We have found several genes that were differently expressed between the favorable and unfavorable prognosis groups and involved in the enriched KEGG pathways based on the TCGA (B4GALNT4, PTK6, and CHAT) and Russian patient cohort data (AKR1C1 and AKR1C3). Additionally, we revealed such genes for the TMPRSS2-ERG prostate cancer molecular subtype (B4GALNT4, ASRGL1, MYBPC1, RGS11, SLC6A14, GALNT13, and ST6GALNAC1). Obtained results contribute to a better understanding of the molecular mechanisms behind prostate cancer progression and could be used for further development of the LAPC prognosis marker panel. Frontiers Media S.A. 2019-08-09 /pmc/articles/PMC6697060/ /pubmed/31447885 http://dx.doi.org/10.3389/fgene.2019.00730 Text en Copyright © 2019 Pudova, Lukyanova, Nyushko, Mikhaylenko, Zaretsky, Snezhkina, Savvateeva, Kobelyatskaya, Melnikova, Volchenko, Efremov, Klimina, Belova, Kiseleva, Kaprin, Alekseev, Krasnov and Kudryavtseva http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Genetics Pudova, Elena A. Lukyanova, Elena N. Nyushko, Kirill M. Mikhaylenko, Dmitry S. Zaretsky, Andrew R. Snezhkina, Anastasiya V. Savvateeva, Maria V. Kobelyatskaya, Anastasiya A. Melnikova, Nataliya V. Volchenko, Nadezhda N. Efremov, Gennady D. Klimina, Kseniya M. Belova, Anastasiya A. Kiseleva, Marina V. Kaprin, Andrey D. Alekseev, Boris Y. Krasnov, George S. Kudryavtseva, Anna V. Differentially Expressed Genes Associated With Prognosis in Locally Advanced Lymph Node-Negative Prostate Cancer |
title | Differentially Expressed Genes Associated With Prognosis in Locally Advanced Lymph Node-Negative Prostate Cancer |
title_full | Differentially Expressed Genes Associated With Prognosis in Locally Advanced Lymph Node-Negative Prostate Cancer |
title_fullStr | Differentially Expressed Genes Associated With Prognosis in Locally Advanced Lymph Node-Negative Prostate Cancer |
title_full_unstemmed | Differentially Expressed Genes Associated With Prognosis in Locally Advanced Lymph Node-Negative Prostate Cancer |
title_short | Differentially Expressed Genes Associated With Prognosis in Locally Advanced Lymph Node-Negative Prostate Cancer |
title_sort | differentially expressed genes associated with prognosis in locally advanced lymph node-negative prostate cancer |
topic | Genetics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6697060/ https://www.ncbi.nlm.nih.gov/pubmed/31447885 http://dx.doi.org/10.3389/fgene.2019.00730 |
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