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Dual Function pH Responsive Bispecific Antibodies for Tumor Targeting and Antigen Depletion in Plasma

Shedding of membrane-bound cell surface proteins, where the extracellular domain is released and found in the circulation is a common phenomenon. A prominent example is CEACAM5 (CEA, CD66e), where the shed domain plays a pivotal role in tumor progression and metastasis. For treatment of solid tumors...

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Detalles Bibliográficos
Autores principales:	Bogen, Jan P., Hinz, Steffen C., Grzeschik, Julius, Ebenig, Aileen, Krah, Simon, Zielonka, Stefan, Kolmar, Harald
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6697062/ https://www.ncbi.nlm.nih.gov/pubmed/31447859 http://dx.doi.org/10.3389/fimmu.2019.01892

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