Considerations for an In Vitro, Cell-Based Testing Platform for Detection of Adverse Drug-Induced Inotropic Effects in Early Drug Development. Part 1: General Considerations for Development of Novel Testing Platforms

Drug-induced effects on cardiac contractility can be assessed through the measurement of the maximal rate of pressure increase in the left ventricle (LVdP/dt(max)) in conscious animals, and such studies are often conducted at the late stage of preclinical drug development. Detection of such effects...

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Detalles Bibliográficos
Autores principales: Guth, Brian D., Engwall, Michael, Eldridge, Sandy, Foley, C. Michael, Guo, Liang, Gintant, Gary, Koerner, John, Parish, Stanley T., Pierson, Jennifer B., Ribeiro, Alexandre J. S., Zabka, Tanja, Chaudhary, Khuram W., Kanda, Yasunari, Berridge, Brian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6697071/
https://www.ncbi.nlm.nih.gov/pubmed/31447679
http://dx.doi.org/10.3389/fphar.2019.00884

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