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Maternal choline supplementation ameliorates Alzheimer’s disease pathology by reducing brain homocysteine levels across multiple generations

The lack of effective treatments for Alzheimer’s disease (AD) is alarming considering the number of people currently affected by this disorder and the projected increase over the next few decades. Elevated homocysteine levels double the risk of developing AD. Choline, a primary dietary source of met...

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Detalles Bibliográficos
Autores principales: Velazquez, Ramon, Ferreira, Eric, Winslow, Wendy, Dave, Nikhil, Piras, Ignazio S., Naymik, Marcus, Huentelman, Matthew J, Tran, An, Caccamo, Antonella, Oddo, Salvatore
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6697226/
https://www.ncbi.nlm.nih.gov/pubmed/30622336
http://dx.doi.org/10.1038/s41380-018-0322-z