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DZNep-mediated apoptosis in B-cell lymphoma is independent of the lymphoma type, EZH2 mutation status and MYC, BCL2 or BCL6 translocations

Enhancer of zeste homolog 2 (EZH2) tri-methylates histone 3 at position lysine 27 (H3K27me3). Overexpression and gain-of-function mutations in EZH2 are regarded as oncogenic drivers in lymphoma and other malignancies due to the silencing of tumor suppressors and differentiation genes. EZH2 inhibitio...

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Detalles Bibliográficos
Autores principales:	Akpa, Chidimma Agatha, Kleo, Karsten, Lenze, Dido, Oker, Elisabeth, Dimitrova, Lora, Hummel, Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6697340/ https://www.ncbi.nlm.nih.gov/pubmed/31419226 http://dx.doi.org/10.1371/journal.pone.0220681

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