Antimony resistance in Leishmania (Viannia) braziliensis clinical isolates from atypical lesions associates with increased ARM56/ARM58 transcripts and reduced drug uptake

BACKGROUND: In addition to the limited therapeutic arsenal and the side effects of antileishmanial agents, drug resistance hinders disease control. In Brazil, Leishmania braziliensis causes atypical (AT) tegumentary leishmaniasis lesions, frequently refractory to treatment. OBJECTIVES: The main goal...

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Detalles Bibliográficos
Autores principales: Rugani, Jeronimo Nunes, Gontijo, Célia Maria Ferreira, Frézard, Frédéric, Soares, Rodrigo Pedro, do Monte-Neto, Rubens Lima
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Instituto Oswaldo Cruz, Ministério da Saúde 2019
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6697410/
https://www.ncbi.nlm.nih.gov/pubmed/31433006
http://dx.doi.org/10.1590/0074-02760190111

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6697410/
https://www.ncbi.nlm.nih.gov/pubmed/31433006
http://dx.doi.org/10.1590/0074-02760190111

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