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Regional and correlative sweat analysis using high-throughput microfluidic sensing patches toward decoding sweat

Recent technological advancements in wearable sensors have made it easier to detect sweat components, but our limited understanding of sweat restricts its application. A critical bottleneck for temporal and regional sweat analysis is achieving uniform, high-throughput fabrication of sweat sensor com...

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Autores principales: Nyein, Hnin Yin Yin, Bariya, Mallika, Kivimäki, Liisa, Uusitalo, Sanna, Liaw, Tiffany Sun, Jansson, Elina, Ahn, Christine Heera, Hangasky, John A., Zhao, Jiangqi, Lin, Yuanjing, Happonen, Tuomas, Chao, Minghan, Liedert, Christina, Zhao, Yingbo, Tai, Li-Chia, Hiltunen, Jussi, Javey, Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6697435/
https://www.ncbi.nlm.nih.gov/pubmed/31453333
http://dx.doi.org/10.1126/sciadv.aaw9906
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author Nyein, Hnin Yin Yin
Bariya, Mallika
Kivimäki, Liisa
Uusitalo, Sanna
Liaw, Tiffany Sun
Jansson, Elina
Ahn, Christine Heera
Hangasky, John A.
Zhao, Jiangqi
Lin, Yuanjing
Happonen, Tuomas
Chao, Minghan
Liedert, Christina
Zhao, Yingbo
Tai, Li-Chia
Hiltunen, Jussi
Javey, Ali
author_facet Nyein, Hnin Yin Yin
Bariya, Mallika
Kivimäki, Liisa
Uusitalo, Sanna
Liaw, Tiffany Sun
Jansson, Elina
Ahn, Christine Heera
Hangasky, John A.
Zhao, Jiangqi
Lin, Yuanjing
Happonen, Tuomas
Chao, Minghan
Liedert, Christina
Zhao, Yingbo
Tai, Li-Chia
Hiltunen, Jussi
Javey, Ali
author_sort Nyein, Hnin Yin Yin
collection PubMed
description Recent technological advancements in wearable sensors have made it easier to detect sweat components, but our limited understanding of sweat restricts its application. A critical bottleneck for temporal and regional sweat analysis is achieving uniform, high-throughput fabrication of sweat sensor components, including microfluidic chip and sensing electrodes. To overcome this challenge, we introduce microfluidic sensing patches mass fabricated via roll-to-roll (R2R) processes. The patch allows sweat capture within a spiral microfluidic for real-time measurement of sweat parameters including [Na(+)], [K(+)], [glucose], and sweat rate in exercise and chemically induced sweat. The patch is demonstrated for investigating regional sweat composition, predicting whole-body fluid/electrolyte loss during exercise, uncovering relationships between sweat metrics, and tracking glucose dynamics to explore sweat-to-blood correlations in healthy and diabetic individuals. By enabling a comprehensive sweat analysis, the presented device is a crucial tool for advancing sweat testing beyond the research stage for point-of-care medical and athletic applications.
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spelling pubmed-66974352019-08-26 Regional and correlative sweat analysis using high-throughput microfluidic sensing patches toward decoding sweat Nyein, Hnin Yin Yin Bariya, Mallika Kivimäki, Liisa Uusitalo, Sanna Liaw, Tiffany Sun Jansson, Elina Ahn, Christine Heera Hangasky, John A. Zhao, Jiangqi Lin, Yuanjing Happonen, Tuomas Chao, Minghan Liedert, Christina Zhao, Yingbo Tai, Li-Chia Hiltunen, Jussi Javey, Ali Sci Adv Research Articles Recent technological advancements in wearable sensors have made it easier to detect sweat components, but our limited understanding of sweat restricts its application. A critical bottleneck for temporal and regional sweat analysis is achieving uniform, high-throughput fabrication of sweat sensor components, including microfluidic chip and sensing electrodes. To overcome this challenge, we introduce microfluidic sensing patches mass fabricated via roll-to-roll (R2R) processes. The patch allows sweat capture within a spiral microfluidic for real-time measurement of sweat parameters including [Na(+)], [K(+)], [glucose], and sweat rate in exercise and chemically induced sweat. The patch is demonstrated for investigating regional sweat composition, predicting whole-body fluid/electrolyte loss during exercise, uncovering relationships between sweat metrics, and tracking glucose dynamics to explore sweat-to-blood correlations in healthy and diabetic individuals. By enabling a comprehensive sweat analysis, the presented device is a crucial tool for advancing sweat testing beyond the research stage for point-of-care medical and athletic applications. American Association for the Advancement of Science 2019-08-16 /pmc/articles/PMC6697435/ /pubmed/31453333 http://dx.doi.org/10.1126/sciadv.aaw9906 Text en Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). http://creativecommons.org/licenses/by-nc/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (http://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.
spellingShingle Research Articles
Nyein, Hnin Yin Yin
Bariya, Mallika
Kivimäki, Liisa
Uusitalo, Sanna
Liaw, Tiffany Sun
Jansson, Elina
Ahn, Christine Heera
Hangasky, John A.
Zhao, Jiangqi
Lin, Yuanjing
Happonen, Tuomas
Chao, Minghan
Liedert, Christina
Zhao, Yingbo
Tai, Li-Chia
Hiltunen, Jussi
Javey, Ali
Regional and correlative sweat analysis using high-throughput microfluidic sensing patches toward decoding sweat
title Regional and correlative sweat analysis using high-throughput microfluidic sensing patches toward decoding sweat
title_full Regional and correlative sweat analysis using high-throughput microfluidic sensing patches toward decoding sweat
title_fullStr Regional and correlative sweat analysis using high-throughput microfluidic sensing patches toward decoding sweat
title_full_unstemmed Regional and correlative sweat analysis using high-throughput microfluidic sensing patches toward decoding sweat
title_short Regional and correlative sweat analysis using high-throughput microfluidic sensing patches toward decoding sweat
title_sort regional and correlative sweat analysis using high-throughput microfluidic sensing patches toward decoding sweat
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6697435/
https://www.ncbi.nlm.nih.gov/pubmed/31453333
http://dx.doi.org/10.1126/sciadv.aaw9906
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