Deep multiomics profiling of brain tumors identifies signaling networks downstream of cancer driver genes

High throughput omics approaches provide an unprecedented opportunity for dissecting molecular mechanisms in cancer biology. Here we present deep profiling of whole proteome, phosphoproteome and transcriptome in two high-grade glioma (HGG) mouse models driven by mutated RTK oncogenes, PDGFRA and NTR...

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Detalles Bibliográficos
Autores principales: Wang, Hong, Diaz, Alexander K., Shaw, Timothy I., Li, Yuxin, Niu, Mingming, Cho, Ji-Hoon, Paugh, Barbara S., Zhang, Yang, Sifford, Jeffrey, Bai, Bing, Wu, Zhiping, Tan, Haiyan, Zhou, Suiping, Hover, Laura D., Tillman, Heather S., Shirinifard, Abbas, Thiagarajan, Suresh, Sablauer, Andras, Pagala, Vishwajeeth, High, Anthony A., Wang, Xusheng, Li, Chunliang, Baker, Suzanne J., Peng, Junmin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6697699/
https://www.ncbi.nlm.nih.gov/pubmed/31420543
http://dx.doi.org/10.1038/s41467-019-11661-4

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