Structural insights into dehydratase substrate selection for the borrelidin and fluvirucin polyketide synthases

Engineered polyketide synthases (PKSs) are promising synthetic biology platforms for the production of chemicals with diverse applications. The dehydratase (DH) domain within modular type I PKSs generates an α,β-unsaturated bond in nascent polyketide intermediates through a dehydration reaction. Sev...

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Detalles Bibliográficos
Autores principales: Barajas, Jesus F., McAndrew, Ryan P., Thompson, Mitchell G., Backman, Tyler W. H., Pang, Bo, de Rond, Tristan, Pereira, Jose H., Benites, Veronica T., Martín, Héctor García, Baidoo, Edward E. K., Hillson, Nathan J., Adams, Paul D., Keasling, Jay D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2019
Materias:
Natural Products - Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6697708/
https://www.ncbi.nlm.nih.gov/pubmed/31115703
http://dx.doi.org/10.1007/s10295-019-02189-z

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