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Interplay between c-Src and the APC/C co-activator Cdh1 regulates mammary tumorigenesis

The Anaphase Promoting Complex (APC) coactivator Cdh1 drives proper cell cycle progression and is implicated in the suppression of tumorigenesis. However, it remains elusive how Cdh1 restrains cancer progression and how tumor cells escape the inhibition of Cdh1. Here we report that Cdh1 suppresses t...

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Detalles Bibliográficos
Autores principales:	Han, Tao, Jiang, Shulong, Zheng, Hong, Yin, Qing, Xie, Mengyu, Little, Margaret R, Yin, Xiu, Chen, Ming, Song, Su Jung, Beg, Amer A., Pandolfi, Pier Paolo, Wan, Lixin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6697746/ https://www.ncbi.nlm.nih.gov/pubmed/31420536 http://dx.doi.org/10.1038/s41467-019-11618-7

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