N-glycosylation-defective splice variants of neuropilin-1 promote metastasis by activating endosomal signals

Neuropilin-1 (NRP1) is an essential transmembrane receptor with a variety of cellular functions. Here, we identify two human NRP1 splice variants resulting from the skipping of exon 4 and 5, respectively, in colorectal cancer (CRC). Both NRP1 variants exhibit increased endocytosis/recycling activity...

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Detalles Bibliográficos
Autores principales: Huang, Xiuping, Ye, Qing, Chen, Min, Li, Aimin, Mi, Wenting, Fang, Yuxin, Zaytseva, Yekaterina Y., O’Connor, Kathleen L., Vander Kooi, Craig W., Liu, Side, She, Qing-Bai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6697747/
https://www.ncbi.nlm.nih.gov/pubmed/31420553
http://dx.doi.org/10.1038/s41467-019-11580-4

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