Cargando…

Dynamic colocalization of 2 simultaneously active VSG expression sites within a single expression-site body in Trypanosoma brucei

Monoallelic exclusion ensures that the African trypanosome Trypanosoma brucei exclusively expresses only 1 of thousands of different variant surface glycoprotein (VSG) coat genes. The active VSG is transcribed from 1 of 15 polycistronic bloodstream-form VSG expression sites (ESs), which are controll...

Descripción completa

Detalles Bibliográficos
Autores principales:	Budzak, James, Kerry, Louise E., Aristodemou, Aris, Hall, Belinda S., Witmer, Kathrin, Kushwaha, Manish, Davies, Carys, Povelones, Megan L., McDonald, Jacquelyn R., Sur, Aakash, Myler, Peter J., Rudenko, Gloria
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2019
Materias:	PNAS Plus
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6697882/ https://www.ncbi.nlm.nih.gov/pubmed/31358644 http://dx.doi.org/10.1073/pnas.1905552116

Ejemplares similares

Histone H1 Plays a Role in Heterochromatin Formation and VSG Expression Site Silencing in Trypanosoma brucei
por: Povelones, Megan L., et al.
Publicado: (2012)

NLP is a novel transcription regulator involved in VSG expression site control in Trypanosoma brucei
por: Narayanan, Mani Shankar, et al.
Publicado: (2011)

Flagellum couples cell shape to motility in Trypanosoma brucei
por: Sun, Stella Y., et al.
Publicado: (2018)

Molecular model of the mitochondrial genome segregation machinery in Trypanosoma brucei
por: Hoffmann, Anneliese, et al.
Publicado: (2018)

An assembly of nuclear bodies associates with the active VSG expression site in African trypanosomes
por: Budzak, James, et al.
Publicado: (2022)

FACT plays a major role in histone dynamics affecting VSG expression site control in Trypanosoma brucei
por: Denninger, Viola, et al.
Publicado: (2014)

Isolation and analysis of the genetic diversity of repertoires of VSG expression site containing telomeres from Trypanosoma brucei gambiense, T. b. brucei and T. equiperdum
por: Young, Rosanna, et al.
Publicado: (2008)

Genome-wide colocalization of RNA–DNA interactions and fusion RNA pairs
por: Yan, Zhangming, et al.
Publicado: (2019)

The FACT subunit TbSpt16 is involved in cell cycle specific control of VSG expression sites in Trypanosoma brucei
por: Denninger, Viola, et al.
Publicado: (2010)

Trypanosoma brucei gambiense Adaptation to Different Mammalian Sera Is Associated with VSG Expression Site Plasticity
por: Cordon-Obras, Carlos, et al.
Publicado: (2013)

Well-positioned nucleosomes punctuate polycistronic pol II transcription units and flank silent VSG gene arrays in Trypanosoma brucei
por: Maree, Johannes Petrus, et al.
Publicado: (2017)

Noncanonical autophagy at ER exit sites regulates procollagen turnover
por: Omari, Shakib, et al.
Publicado: (2018)

Enzyme annotation for orphan and novel reactions using knowledge of substrate reactive sites
por: Hadadi, Noushin, et al.
Publicado: (2019)

Active site voltage clamp fluorometry of the sodium glucose cotransporter hSGLT1
por: Gorraitz, Edurne, et al.
Publicado: (2017)

Deep mutational analysis reveals functional trade-offs in the sequences of EGFR autophosphorylation sites
por: Cantor, Aaron J., et al.
Publicado: (2018)

Biosynthesis of the nitrogenase active-site cofactor precursor NifB-co in Saccharomyces cerevisiae
por: Burén, Stefan, et al.
Publicado: (2019)

TOPO3α Influences Antigenic Variation by Monitoring Expression-Site-Associated VSG Switching in Trypanosoma brucei
por: Kim, Hee-Sook, et al.
Publicado: (2010)

Nonenzymatic release of N7-methylguanine channels repair of abasic sites into an AP endonuclease-independent pathway in Arabidopsis
por: Barbado, Casimiro, et al.
Publicado: (2018)

Structural characterization of the D290V mutation site in hnRNPA2 low-complexity–domain polymers
por: Murray, Dylan T., et al.
Publicado: (2018)

Site-specific phosphorylation of myosin binding protein-C coordinates thin and thick filament activation in cardiac muscle
por: Ponnam, Saraswathi, et al.
Publicado: (2019)

Remodeling of ER–plasma membrane contact sites but not STIM1 phosphorylation inhibits Ca(2+) influx in mitosis
por: Yu, Fang, et al.
Publicado: (2019)

Molecular blueprint of allosteric binding sites in a homologue of the agonist-binding domain of the α7 nicotinic acetylcholine receptor
por: Spurny, Radovan, et al.
Publicado: (2015)

Highly ABA-Induced 1 (HAI1)-Interacting protein HIN1 and drought acclimation-enhanced splicing efficiency at intron retention sites
por: Chong, Geeng Loo, et al.
Publicado: (2019)

Predictability of human differential gene expression
por: Crow, Megan, et al.
Publicado: (2019)

A modern maximum-likelihood theory for high-dimensional logistic regression
por: Sur, Pragya, et al.
Publicado: (2019)

Pedal to the Metal: Nuclear Splicing Bodies Turbo-Charge VSG mRNA Production in African Trypanosomes
por: Budzak, James, et al.
Publicado: (2022)

Gene expression distribution deconvolution in single-cell RNA sequencing
por: Wang, Jingshu, et al.
Publicado: (2018)

Distinct facial expressions represent pain and pleasure across cultures
por: Chen, Chaona, et al.
Publicado: (2018)

Global impacts of chromosomal imbalance on gene expression in Arabidopsis and other taxa
por: Hou, Jie, et al.
Publicado: (2018)

Universal method for robust detection of circadian state from gene expression
por: Braun, Rosemary, et al.
Publicado: (2018)

Analytical distributions for detailed models of stochastic gene expression in eukaryotic cells
por: Cao, Zhixing, et al.
Publicado: (2020)

An RNA structure-mediated, posttranscriptional model of human α-1-antitrypsin expression
por: Corley, Meredith, et al.
Publicado: (2017)

Germline genetic polymorphisms influence tumor gene expression and immune cell infiltration
por: Lim, Yoong Wearn, et al.
Publicado: (2018)

African trypanosomes expressing multiple VSGs are rapidly eliminated by the host immune system
por: Aresta-Branco, Francisco, et al.
Publicado: (2019)

Agrobacteria reprogram virulence gene expression by controlled release of host-conjugated signals
por: Wang, Chao, et al.
Publicado: (2019)

Paclitaxel-induced epithelial damage and ectopic MMP-13 expression promotes neurotoxicity in zebrafish
por: Lisse, Thomas S., et al.
Publicado: (2016)

Transcription factor profiling reveals molecular choreography and key regulators of human retrotransposon expression
por: Sun, Xiaoji, et al.
Publicado: (2018)

Expression of ABCA4 in the retinal pigment epithelium and its implications for Stargardt macular degeneration
por: Lenis, Tamara L., et al.
Publicado: (2018)

Six6 and Six7 coordinately regulate expression of middle-wavelength opsins in zebrafish
por: Ogawa, Yohey, et al.
Publicado: (2019)

mRNA structure regulates protein expression through changes in functional half-life
por: Mauger, David M., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_5i2vn0l0pbeo655ifurl3805ce