The peroxidase PRDX1 inhibits the activated phenotype in mammary fibroblasts through regulating c-Jun N-terminal kinases

BACKGROUND: Reactive oxygen species (ROS), including hydrogen peroxide, drive differentiation of normal fibroblasts into activated fibroblasts, which can generate high amounts of hydrogen peroxide themselves, thereby increasing oxidative stress in the microenvironment. This way, activated fibroblast...

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Detalles Bibliográficos
Autores principales: Jezierska-Drutel, Agnieszka, Attaran, Shireen, Hopkins, Barbara L., Skoko, John J., Rosenzweig, Steven A., Neumann, Carola A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6697950/
https://www.ncbi.nlm.nih.gov/pubmed/31419957
http://dx.doi.org/10.1186/s12885-019-6031-4

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