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Physical Exercise Increased Brain-Derived Neurotrophic Factor in Elderly Population with Depression

BACKGROUND: Depression is very common in the elderly population. Physical exercise is one of the non-pharmacological procedures that promise to be a solution to improve the severity of depression. Brain-Derived Neurotrophic Factor (BDNF) plays a role in maintaining the survival of neuronal cells and...

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Autores principales: Kurdi, Fauziah Nuraini, Flora, Rostika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Republic of Macedonia 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6698103/
https://www.ncbi.nlm.nih.gov/pubmed/31456825
http://dx.doi.org/10.3889/oamjms.2019.574
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author Kurdi, Fauziah Nuraini
Flora, Rostika
author_facet Kurdi, Fauziah Nuraini
Flora, Rostika
author_sort Kurdi, Fauziah Nuraini
collection PubMed
description BACKGROUND: Depression is very common in the elderly population. Physical exercise is one of the non-pharmacological procedures that promise to be a solution to improve the severity of depression. Brain-Derived Neurotrophic Factor (BDNF) plays a role in maintaining the survival of neuronal cells and in the regulation of synapse plasticity, affecting serotonin production in the hippocampus and thus the depressive symptoms. AIM: This study aimed to assess the role of physical exercise in affecting BDNF levels in elderly with depression. METHODS: Thirty-five elderly women (age ≥ 50 years) with depressive episodes based on Diagnostic and Statistical Manual of Mental Disorders (DSM)-V criteria were enrolled as treatment group, and 35 elderly women without depressive episodes were enrolled as control group, and underwent physical exercise in the form of treadmill with a speed of 6 km/h for 15 minutes. Physical exercise was carried out once a day for 28 days. As much as 1 ml of blood from the study, subjects were obtained from the cubital vein before the exercise commenced. Brain-Derived Neurotrophic Factor (BDNF) serum level was assessed by Enzyme-Linked Immunosorbent Assay (ELISA). Data were presented in the form of mean ± SD. An independent T-test was used to test levels after exercise in the depression group compared to the non-depression group. RESULTS: Pre-exercise BDNF levels in the depression group were lower than the group of elderly without depression. Physical exercise increased BDNF production in both elderly groups with and without depression. In the depression group, the increasing percentage of BDNF level was higher compared to non-depressive elderly. CONCLUSION: The increasing percentage of BDNF level was found to be higher in depressive elderly performing physical exercise. Physical exercise may be beneficial in supporting the therapy of elderly with depression.
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spelling pubmed-66981032019-08-27 Physical Exercise Increased Brain-Derived Neurotrophic Factor in Elderly Population with Depression Kurdi, Fauziah Nuraini Flora, Rostika Open Access Maced J Med Sci Basic Science BACKGROUND: Depression is very common in the elderly population. Physical exercise is one of the non-pharmacological procedures that promise to be a solution to improve the severity of depression. Brain-Derived Neurotrophic Factor (BDNF) plays a role in maintaining the survival of neuronal cells and in the regulation of synapse plasticity, affecting serotonin production in the hippocampus and thus the depressive symptoms. AIM: This study aimed to assess the role of physical exercise in affecting BDNF levels in elderly with depression. METHODS: Thirty-five elderly women (age ≥ 50 years) with depressive episodes based on Diagnostic and Statistical Manual of Mental Disorders (DSM)-V criteria were enrolled as treatment group, and 35 elderly women without depressive episodes were enrolled as control group, and underwent physical exercise in the form of treadmill with a speed of 6 km/h for 15 minutes. Physical exercise was carried out once a day for 28 days. As much as 1 ml of blood from the study, subjects were obtained from the cubital vein before the exercise commenced. Brain-Derived Neurotrophic Factor (BDNF) serum level was assessed by Enzyme-Linked Immunosorbent Assay (ELISA). Data were presented in the form of mean ± SD. An independent T-test was used to test levels after exercise in the depression group compared to the non-depression group. RESULTS: Pre-exercise BDNF levels in the depression group were lower than the group of elderly without depression. Physical exercise increased BDNF production in both elderly groups with and without depression. In the depression group, the increasing percentage of BDNF level was higher compared to non-depressive elderly. CONCLUSION: The increasing percentage of BDNF level was found to be higher in depressive elderly performing physical exercise. Physical exercise may be beneficial in supporting the therapy of elderly with depression. Republic of Macedonia 2019-07-12 /pmc/articles/PMC6698103/ /pubmed/31456825 http://dx.doi.org/10.3889/oamjms.2019.574 Text en Copyright: © 2019 Fauziah Nuraini Kurdi, Rostika Flora. http://creativecommons.org/licenses/CC BY-NC/4.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).
spellingShingle Basic Science
Kurdi, Fauziah Nuraini
Flora, Rostika
Physical Exercise Increased Brain-Derived Neurotrophic Factor in Elderly Population with Depression
title Physical Exercise Increased Brain-Derived Neurotrophic Factor in Elderly Population with Depression
title_full Physical Exercise Increased Brain-Derived Neurotrophic Factor in Elderly Population with Depression
title_fullStr Physical Exercise Increased Brain-Derived Neurotrophic Factor in Elderly Population with Depression
title_full_unstemmed Physical Exercise Increased Brain-Derived Neurotrophic Factor in Elderly Population with Depression
title_short Physical Exercise Increased Brain-Derived Neurotrophic Factor in Elderly Population with Depression
title_sort physical exercise increased brain-derived neurotrophic factor in elderly population with depression
topic Basic Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6698103/
https://www.ncbi.nlm.nih.gov/pubmed/31456825
http://dx.doi.org/10.3889/oamjms.2019.574
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