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Use of intrawound vancomycin powder against postoperative infection after spine surgery

Local application of vancomycin has recently become widely used in spine surgery. However, local application is not included in the indication and has not been approved by the US Food and Drug Administration (FDA). Thus, we searched for reports with “intra wound-vancomycin” and “SSI” as keywords in...

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Autores principales: Takahashi, Hiroshi, Iida, Yasuaki, Yokoyama, Yuichirou, Hasegawa, Keiji, Tsuge, Shintaro, Fukutake, Katsunori, Nakamura, Kazumasa, Wada, Akihito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society for Spine Surgery and Related Research 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6698544/
https://www.ncbi.nlm.nih.gov/pubmed/31440641
http://dx.doi.org/10.22603/ssrr.2016-0002
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author Takahashi, Hiroshi
Iida, Yasuaki
Yokoyama, Yuichirou
Hasegawa, Keiji
Tsuge, Shintaro
Fukutake, Katsunori
Nakamura, Kazumasa
Wada, Akihito
author_facet Takahashi, Hiroshi
Iida, Yasuaki
Yokoyama, Yuichirou
Hasegawa, Keiji
Tsuge, Shintaro
Fukutake, Katsunori
Nakamura, Kazumasa
Wada, Akihito
author_sort Takahashi, Hiroshi
collection PubMed
description Local application of vancomycin has recently become widely used in spine surgery. However, local application is not included in the indication and has not been approved by the US Food and Drug Administration (FDA). Thus, we searched for reports with “intra wound-vancomycin” and “SSI” as keywords in the MEDLINE database, and investigated the efficacy, problems with use, and future prospects based on these reports. Intrawound vancomycin was described as effective in most of the reports, but was found to have no effect or to aggravate the condition in some reports. A toxic effect on osteoblasts due to a high local concentration was described in some reports, whereas local application was found to be safe in other studies. The amount of vancomycin used and the administration method varied among the reports. Overall, the results suggest that intrawound vancomycin is clinically effective, but this has yet to be established in a randomized controlled trial. There is a need to identify cases that should be selected for this treatment and to investigate the dose and optimum concentration of vancomycin for clinical use.
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spelling pubmed-66985442019-08-22 Use of intrawound vancomycin powder against postoperative infection after spine surgery Takahashi, Hiroshi Iida, Yasuaki Yokoyama, Yuichirou Hasegawa, Keiji Tsuge, Shintaro Fukutake, Katsunori Nakamura, Kazumasa Wada, Akihito Spine Surg Relat Res Review Article Local application of vancomycin has recently become widely used in spine surgery. However, local application is not included in the indication and has not been approved by the US Food and Drug Administration (FDA). Thus, we searched for reports with “intra wound-vancomycin” and “SSI” as keywords in the MEDLINE database, and investigated the efficacy, problems with use, and future prospects based on these reports. Intrawound vancomycin was described as effective in most of the reports, but was found to have no effect or to aggravate the condition in some reports. A toxic effect on osteoblasts due to a high local concentration was described in some reports, whereas local application was found to be safe in other studies. The amount of vancomycin used and the administration method varied among the reports. Overall, the results suggest that intrawound vancomycin is clinically effective, but this has yet to be established in a randomized controlled trial. There is a need to identify cases that should be selected for this treatment and to investigate the dose and optimum concentration of vancomycin for clinical use. The Japanese Society for Spine Surgery and Related Research 2018-01-27 /pmc/articles/PMC6698544/ /pubmed/31440641 http://dx.doi.org/10.22603/ssrr.2016-0002 Text en Copyright © 2018 by The Japanese Society for Spine Surgery and Related Research https://creativecommons.org/licenses/by-nc-nd/4.0/ Spine Surgery and Related Research is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
Takahashi, Hiroshi
Iida, Yasuaki
Yokoyama, Yuichirou
Hasegawa, Keiji
Tsuge, Shintaro
Fukutake, Katsunori
Nakamura, Kazumasa
Wada, Akihito
Use of intrawound vancomycin powder against postoperative infection after spine surgery
title Use of intrawound vancomycin powder against postoperative infection after spine surgery
title_full Use of intrawound vancomycin powder against postoperative infection after spine surgery
title_fullStr Use of intrawound vancomycin powder against postoperative infection after spine surgery
title_full_unstemmed Use of intrawound vancomycin powder against postoperative infection after spine surgery
title_short Use of intrawound vancomycin powder against postoperative infection after spine surgery
title_sort use of intrawound vancomycin powder against postoperative infection after spine surgery
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6698544/
https://www.ncbi.nlm.nih.gov/pubmed/31440641
http://dx.doi.org/10.22603/ssrr.2016-0002
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