Neurosteroid and benzodiazepine combination therapy reduces status epilepticus and long‐term effects of whole‐body sarin exposure in rats

OBJECTIVE: Our objective was to evaluate the protective efficacy of the neurosteroid pregnanolone (3α‐hydroxy‐5β pregnan‐20‐one), a GABA(A) receptor‐positive allosteric modulator, as an adjunct to benzodiazepine therapy against the chemical warfare nerve agent (CWNA) sarin (GB), using whole‐body exp...

Descripción completa

Detalles Bibliográficos
Autores principales: Lumley, Lucille, Miller, Dennis, Muse, William T., Marrero‐Rosado, Brenda, de Araujo Furtado, Marcio, Stone, Michael, McGuire, Jeffrey, Whalley, Christopher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Full‐length Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6698686/
https://www.ncbi.nlm.nih.gov/pubmed/31440720
http://dx.doi.org/10.1002/epi4.12344

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6698686/
https://www.ncbi.nlm.nih.gov/pubmed/31440720
http://dx.doi.org/10.1002/epi4.12344

Ejemplares similares