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The effect of adenine protonation on RNA phosphodiester backbone bond cleavage elucidated by deaza-nucleobase modifications and mass spectrometry

The catalytic strategies of small self-cleaving ribozymes often involve interactions between nucleobases and the ribonucleic acid (RNA) backbone. Here we show that multiply protonated, gaseous RNA has an intrinsic preference for the formation of ionic hydrogen bonds between adenine protonated at N3...

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Detalles Bibliográficos
Autores principales:	Fuchs, Elisabeth, Falschlunger, Christoph, Micura, Ronald, Breuker, Kathrin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2019
Materias:	Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6698743/ https://www.ncbi.nlm.nih.gov/pubmed/31276590 http://dx.doi.org/10.1093/nar/gkz574

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