Metal sensing and regulation of adaptive responses to manganese limitation by MtsR is critical for group A streptococcus virulence

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Pathogenic bacteria encounter host-imposed manganese (Mn) limitation during infection. Herein we report that in the human pathogen Streptococcus pyogenes, the adaptive response to Mn limitation is controlled by a DtxR family metalloregulator, MtsR. Genes upregulated by MtsR during Mn limitation incl...

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Detalles Bibliográficos
Autores principales: Do, Hackwon, Makthal, Nishanth, Chandrangsu, Pete, Olsen, Randall J, Helmann, John D, Musser, James M, Kumaraswami, Muthiah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6698748/
https://www.ncbi.nlm.nih.gov/pubmed/31188450
http://dx.doi.org/10.1093/nar/gkz524
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