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Deformable abdominal phantom for the validation of real‐time image guidance and deformable dose accumulation
PURPOSE: End‐to‐end testing with quality assurance (QA) phantoms for deformable dose accumulation and real‐time image‐guided radiotherapy (IGRT) has recently been recommended by American Association of Physicists in Medicine (AAPM) Task Groups 132 and 76. The goal of this work was to develop a defor...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6698755/ https://www.ncbi.nlm.nih.gov/pubmed/31355997 http://dx.doi.org/10.1002/acm2.12687 |
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author | Matrosic, Charles K. Hull, Jennifer Palmer, Benjamin Culberson, Wesley Bednarz, Bryan |
author_facet | Matrosic, Charles K. Hull, Jennifer Palmer, Benjamin Culberson, Wesley Bednarz, Bryan |
author_sort | Matrosic, Charles K. |
collection | PubMed |
description | PURPOSE: End‐to‐end testing with quality assurance (QA) phantoms for deformable dose accumulation and real‐time image‐guided radiotherapy (IGRT) has recently been recommended by American Association of Physicists in Medicine (AAPM) Task Groups 132 and 76. The goal of this work was to develop a deformable abdominal phantom containing a deformable three‐dimensional dosimeter that could provide robust testing of these systems. METHODS: The deformable abdominal phantom was fabricated from polyvinyl chloride plastisol and phantom motion was simulated with a programmable motion stage and plunger. A deformable normoxic polyacrylamide gel (nPAG) dosimeter was incorporated into the phantom apparatus to represent a liver tumor. Dosimeter data were acquired using magnetic resonance imaging (MRI). Static measurements were compared to planned dose distributions. Static and dynamic deformations were used to simulate inter‐ and intrafractional motion in the phantom and measurements were compared to baseline measurements. RESULTS: The statically irradiated dosimeters matched the planned dose distribution with an average γ pass rates of 97.0 ± 0.5% and 97.5 ± 0.2% for 3%/5 mm and 5%/5 mm criteria, respectively. Static deformations caused measured dose distribution shifts toward the phantom plunger. During the dynamic deformation experiment, the dosimeter that utilized beam gating showed an improvement in the γ pass rate compared to the dosimeter that did not. CONCLUSIONS: A deformable abdominal phantom apparatus which incorporates a deformable nPAG dosimeter was developed to test real‐time IGRT systems and deformable dose accumulation algorithms. This apparatus was used to benchmark simple static irradiations in which it was found that measurements match well to the planned distributions. Deformable dose accumulation could be tested by directly measuring the shifts and blurring of the target dose due to interfractional organ deformation and motion. Dosimetric improvements were achieved from the motion management during intrafractional motion. |
format | Online Article Text |
id | pubmed-6698755 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-66987552019-08-22 Deformable abdominal phantom for the validation of real‐time image guidance and deformable dose accumulation Matrosic, Charles K. Hull, Jennifer Palmer, Benjamin Culberson, Wesley Bednarz, Bryan J Appl Clin Med Phys Radiation Oncology Physics PURPOSE: End‐to‐end testing with quality assurance (QA) phantoms for deformable dose accumulation and real‐time image‐guided radiotherapy (IGRT) has recently been recommended by American Association of Physicists in Medicine (AAPM) Task Groups 132 and 76. The goal of this work was to develop a deformable abdominal phantom containing a deformable three‐dimensional dosimeter that could provide robust testing of these systems. METHODS: The deformable abdominal phantom was fabricated from polyvinyl chloride plastisol and phantom motion was simulated with a programmable motion stage and plunger. A deformable normoxic polyacrylamide gel (nPAG) dosimeter was incorporated into the phantom apparatus to represent a liver tumor. Dosimeter data were acquired using magnetic resonance imaging (MRI). Static measurements were compared to planned dose distributions. Static and dynamic deformations were used to simulate inter‐ and intrafractional motion in the phantom and measurements were compared to baseline measurements. RESULTS: The statically irradiated dosimeters matched the planned dose distribution with an average γ pass rates of 97.0 ± 0.5% and 97.5 ± 0.2% for 3%/5 mm and 5%/5 mm criteria, respectively. Static deformations caused measured dose distribution shifts toward the phantom plunger. During the dynamic deformation experiment, the dosimeter that utilized beam gating showed an improvement in the γ pass rate compared to the dosimeter that did not. CONCLUSIONS: A deformable abdominal phantom apparatus which incorporates a deformable nPAG dosimeter was developed to test real‐time IGRT systems and deformable dose accumulation algorithms. This apparatus was used to benchmark simple static irradiations in which it was found that measurements match well to the planned distributions. Deformable dose accumulation could be tested by directly measuring the shifts and blurring of the target dose due to interfractional organ deformation and motion. Dosimetric improvements were achieved from the motion management during intrafractional motion. John Wiley and Sons Inc. 2019-07-29 /pmc/articles/PMC6698755/ /pubmed/31355997 http://dx.doi.org/10.1002/acm2.12687 Text en © 2019 The Authors. Journal of Applied Clinical Medical Physics published by Wiley Periodicals, Inc. on behalf of American Association of Physicists in Medicine. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Radiation Oncology Physics Matrosic, Charles K. Hull, Jennifer Palmer, Benjamin Culberson, Wesley Bednarz, Bryan Deformable abdominal phantom for the validation of real‐time image guidance and deformable dose accumulation |
title | Deformable abdominal phantom for the validation of real‐time image guidance and deformable dose accumulation |
title_full | Deformable abdominal phantom for the validation of real‐time image guidance and deformable dose accumulation |
title_fullStr | Deformable abdominal phantom for the validation of real‐time image guidance and deformable dose accumulation |
title_full_unstemmed | Deformable abdominal phantom for the validation of real‐time image guidance and deformable dose accumulation |
title_short | Deformable abdominal phantom for the validation of real‐time image guidance and deformable dose accumulation |
title_sort | deformable abdominal phantom for the validation of real‐time image guidance and deformable dose accumulation |
topic | Radiation Oncology Physics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6698755/ https://www.ncbi.nlm.nih.gov/pubmed/31355997 http://dx.doi.org/10.1002/acm2.12687 |
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