Cargando…

Deformable abdominal phantom for the validation of real‐time image guidance and deformable dose accumulation

PURPOSE: End‐to‐end testing with quality assurance (QA) phantoms for deformable dose accumulation and real‐time image‐guided radiotherapy (IGRT) has recently been recommended by American Association of Physicists in Medicine (AAPM) Task Groups 132 and 76. The goal of this work was to develop a defor...

Descripción completa

Detalles Bibliográficos
Autores principales: Matrosic, Charles K., Hull, Jennifer, Palmer, Benjamin, Culberson, Wesley, Bednarz, Bryan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6698755/
https://www.ncbi.nlm.nih.gov/pubmed/31355997
http://dx.doi.org/10.1002/acm2.12687
_version_ 1783444608312672256
author Matrosic, Charles K.
Hull, Jennifer
Palmer, Benjamin
Culberson, Wesley
Bednarz, Bryan
author_facet Matrosic, Charles K.
Hull, Jennifer
Palmer, Benjamin
Culberson, Wesley
Bednarz, Bryan
author_sort Matrosic, Charles K.
collection PubMed
description PURPOSE: End‐to‐end testing with quality assurance (QA) phantoms for deformable dose accumulation and real‐time image‐guided radiotherapy (IGRT) has recently been recommended by American Association of Physicists in Medicine (AAPM) Task Groups 132 and 76. The goal of this work was to develop a deformable abdominal phantom containing a deformable three‐dimensional dosimeter that could provide robust testing of these systems. METHODS: The deformable abdominal phantom was fabricated from polyvinyl chloride plastisol and phantom motion was simulated with a programmable motion stage and plunger. A deformable normoxic polyacrylamide gel (nPAG) dosimeter was incorporated into the phantom apparatus to represent a liver tumor. Dosimeter data were acquired using magnetic resonance imaging (MRI). Static measurements were compared to planned dose distributions. Static and dynamic deformations were used to simulate inter‐ and intrafractional motion in the phantom and measurements were compared to baseline measurements. RESULTS: The statically irradiated dosimeters matched the planned dose distribution with an average γ pass rates of 97.0 ± 0.5% and 97.5 ± 0.2% for 3%/5 mm and 5%/5 mm criteria, respectively. Static deformations caused measured dose distribution shifts toward the phantom plunger. During the dynamic deformation experiment, the dosimeter that utilized beam gating showed an improvement in the γ pass rate compared to the dosimeter that did not. CONCLUSIONS: A deformable abdominal phantom apparatus which incorporates a deformable nPAG dosimeter was developed to test real‐time IGRT systems and deformable dose accumulation algorithms. This apparatus was used to benchmark simple static irradiations in which it was found that measurements match well to the planned distributions. Deformable dose accumulation could be tested by directly measuring the shifts and blurring of the target dose due to interfractional organ deformation and motion. Dosimetric improvements were achieved from the motion management during intrafractional motion.
format Online
Article
Text
id pubmed-6698755
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-66987552019-08-22 Deformable abdominal phantom for the validation of real‐time image guidance and deformable dose accumulation Matrosic, Charles K. Hull, Jennifer Palmer, Benjamin Culberson, Wesley Bednarz, Bryan J Appl Clin Med Phys Radiation Oncology Physics PURPOSE: End‐to‐end testing with quality assurance (QA) phantoms for deformable dose accumulation and real‐time image‐guided radiotherapy (IGRT) has recently been recommended by American Association of Physicists in Medicine (AAPM) Task Groups 132 and 76. The goal of this work was to develop a deformable abdominal phantom containing a deformable three‐dimensional dosimeter that could provide robust testing of these systems. METHODS: The deformable abdominal phantom was fabricated from polyvinyl chloride plastisol and phantom motion was simulated with a programmable motion stage and plunger. A deformable normoxic polyacrylamide gel (nPAG) dosimeter was incorporated into the phantom apparatus to represent a liver tumor. Dosimeter data were acquired using magnetic resonance imaging (MRI). Static measurements were compared to planned dose distributions. Static and dynamic deformations were used to simulate inter‐ and intrafractional motion in the phantom and measurements were compared to baseline measurements. RESULTS: The statically irradiated dosimeters matched the planned dose distribution with an average γ pass rates of 97.0 ± 0.5% and 97.5 ± 0.2% for 3%/5 mm and 5%/5 mm criteria, respectively. Static deformations caused measured dose distribution shifts toward the phantom plunger. During the dynamic deformation experiment, the dosimeter that utilized beam gating showed an improvement in the γ pass rate compared to the dosimeter that did not. CONCLUSIONS: A deformable abdominal phantom apparatus which incorporates a deformable nPAG dosimeter was developed to test real‐time IGRT systems and deformable dose accumulation algorithms. This apparatus was used to benchmark simple static irradiations in which it was found that measurements match well to the planned distributions. Deformable dose accumulation could be tested by directly measuring the shifts and blurring of the target dose due to interfractional organ deformation and motion. Dosimetric improvements were achieved from the motion management during intrafractional motion. John Wiley and Sons Inc. 2019-07-29 /pmc/articles/PMC6698755/ /pubmed/31355997 http://dx.doi.org/10.1002/acm2.12687 Text en © 2019 The Authors. Journal of Applied Clinical Medical Physics published by Wiley Periodicals, Inc. on behalf of American Association of Physicists in Medicine. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Radiation Oncology Physics
Matrosic, Charles K.
Hull, Jennifer
Palmer, Benjamin
Culberson, Wesley
Bednarz, Bryan
Deformable abdominal phantom for the validation of real‐time image guidance and deformable dose accumulation
title Deformable abdominal phantom for the validation of real‐time image guidance and deformable dose accumulation
title_full Deformable abdominal phantom for the validation of real‐time image guidance and deformable dose accumulation
title_fullStr Deformable abdominal phantom for the validation of real‐time image guidance and deformable dose accumulation
title_full_unstemmed Deformable abdominal phantom for the validation of real‐time image guidance and deformable dose accumulation
title_short Deformable abdominal phantom for the validation of real‐time image guidance and deformable dose accumulation
title_sort deformable abdominal phantom for the validation of real‐time image guidance and deformable dose accumulation
topic Radiation Oncology Physics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6698755/
https://www.ncbi.nlm.nih.gov/pubmed/31355997
http://dx.doi.org/10.1002/acm2.12687
work_keys_str_mv AT matrosiccharlesk deformableabdominalphantomforthevalidationofrealtimeimageguidanceanddeformabledoseaccumulation
AT hulljennifer deformableabdominalphantomforthevalidationofrealtimeimageguidanceanddeformabledoseaccumulation
AT palmerbenjamin deformableabdominalphantomforthevalidationofrealtimeimageguidanceanddeformabledoseaccumulation
AT culbersonwesley deformableabdominalphantomforthevalidationofrealtimeimageguidanceanddeformabledoseaccumulation
AT bednarzbryan deformableabdominalphantomforthevalidationofrealtimeimageguidanceanddeformabledoseaccumulation