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Catalytic Knockdown of miR-21 by Artificial Ribonuclease: Biological Performance in Tumor Model

Control of the expression of oncogenic small non-coding RNAs, notably microRNAs (miRNAs), is an attractive therapeutic approach. We report a design platform for catalytic knockdown of miRNA targets with artificial, sequence-specific ribonucleases. miRNases comprise a peptide [(LeuArg)(2)Gly](2) capa...

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Detalles Bibliográficos
Autores principales:	Patutina, Olga A., Miroshnichenko, Svetlana K., Mironova, Nadezhda L., Sen’kova, Aleksandra V., Bichenkova, Elena V., Clarke, David J., Vlassov, Valentin V., Zenkova, Marina A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6698794/ https://www.ncbi.nlm.nih.gov/pubmed/31456683 http://dx.doi.org/10.3389/fphar.2019.00879

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