Integration of Aqueous Two-Phase Extraction as Cell Harvest and Capture Operation in the Manufacturing Process of Monoclonal Antibodies

Substantial improvements have been made to cell culturing processes (e.g., higher product titer) in recent years by raising cell densities and optimizing cultivation time. However, this has been accompanied by an increase in product-related impurities and therefore greater challenges in subsequent c...

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Detalles Bibliográficos
Autores principales: Schmidt, Axel, Richter, Michael, Rudolph, Frederik, Strube, Jochen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6698824/
https://www.ncbi.nlm.nih.gov/pubmed/31548537
http://dx.doi.org/10.3390/antib6040021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6698824/
https://www.ncbi.nlm.nih.gov/pubmed/31548537
http://dx.doi.org/10.3390/antib6040021

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