Pyrrolobenzodiazepine Antibody-Drug Conjugates Designed for Stable Thiol Conjugation

Thiosuccinimide-linked antibody-drug conjugates (ADCs) are susceptible to drug loss over time due to a retro-Michael reaction, which can be prevented by selecting stable conjugation positions or hydrolysis of the thiosuccinimide. Here, we investigate pyrrolobenzodiazepine (PBD) ADC drug-linkers equi...

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Detalles Bibliográficos
Autores principales: Christie, R. James, Tiberghien, Arnaud C., Du, Qun, Bezabeh, Binyam, Fleming, Ryan, Shannon, Amanda, Mao, Shenlan, Breen, Shannon, Zhang, Jing, Zhong, Haihong, Harper, Jay, Wu, Herren, Howard, Philip W., Gao, Changshou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6698857/
https://www.ncbi.nlm.nih.gov/pubmed/31548535
http://dx.doi.org/10.3390/antib6040020

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6698857/
https://www.ncbi.nlm.nih.gov/pubmed/31548535
http://dx.doi.org/10.3390/antib6040020

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