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Anticytokine Autoantibodies: Association with Infection and Immune Dysregulation
The association of autoantibodies to cytokines with immune deficiency, autoimmunity and/or immune dysregulation is increasingly being recognized. For example, autoantibodies to interferon gamma have been found to be associated with chronic, treatment refractory infections with intracellular organism...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6698860/ https://www.ncbi.nlm.nih.gov/pubmed/31557985 http://dx.doi.org/10.3390/antib5010003 |
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author | Knight, Vijaya Merkel, Patricia A. O’Sullivan, Michael D. |
author_facet | Knight, Vijaya Merkel, Patricia A. O’Sullivan, Michael D. |
author_sort | Knight, Vijaya |
collection | PubMed |
description | The association of autoantibodies to cytokines with immune deficiency, autoimmunity and/or immune dysregulation is increasingly being recognized. For example, autoantibodies to interferon gamma have been found to be associated with chronic, treatment refractory infections with intracellular organisms such as mycobacteria, autoantibodies to interleukin 17 with chronic mucocutaneous candidiasis, and anti-interferon alpha autoantibodies with systemic lupus erythematosus. While low titer autoantibodies to these and other cytokines may be detected in normal individuals, patients with infectious or autoimmune manifestations tend to have high titer autoantibodies that may block or potentiate the function of the respective cytokine. Recognition of these autoantibodies is important because it may direct treatment toward a combination of adjunctive immunotherapy to modulate the autoantibody level while continuing with appropriate anti-microbial therapy. This review focuses on the anti-cytokine autoantibodies documented to date, their autoimmune, immune dysregulation and infectious disease associations, methods for detection of these antibodies and potential treatment options. |
format | Online Article Text |
id | pubmed-6698860 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-66988602019-09-05 Anticytokine Autoantibodies: Association with Infection and Immune Dysregulation Knight, Vijaya Merkel, Patricia A. O’Sullivan, Michael D. Antibodies (Basel) Review The association of autoantibodies to cytokines with immune deficiency, autoimmunity and/or immune dysregulation is increasingly being recognized. For example, autoantibodies to interferon gamma have been found to be associated with chronic, treatment refractory infections with intracellular organisms such as mycobacteria, autoantibodies to interleukin 17 with chronic mucocutaneous candidiasis, and anti-interferon alpha autoantibodies with systemic lupus erythematosus. While low titer autoantibodies to these and other cytokines may be detected in normal individuals, patients with infectious or autoimmune manifestations tend to have high titer autoantibodies that may block or potentiate the function of the respective cytokine. Recognition of these autoantibodies is important because it may direct treatment toward a combination of adjunctive immunotherapy to modulate the autoantibody level while continuing with appropriate anti-microbial therapy. This review focuses on the anti-cytokine autoantibodies documented to date, their autoimmune, immune dysregulation and infectious disease associations, methods for detection of these antibodies and potential treatment options. MDPI 2016-01-15 /pmc/articles/PMC6698860/ /pubmed/31557985 http://dx.doi.org/10.3390/antib5010003 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. https://creativecommons.org/licenses/by/4.0/This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ). |
spellingShingle | Review Knight, Vijaya Merkel, Patricia A. O’Sullivan, Michael D. Anticytokine Autoantibodies: Association with Infection and Immune Dysregulation |
title | Anticytokine Autoantibodies: Association with Infection and Immune Dysregulation |
title_full | Anticytokine Autoantibodies: Association with Infection and Immune Dysregulation |
title_fullStr | Anticytokine Autoantibodies: Association with Infection and Immune Dysregulation |
title_full_unstemmed | Anticytokine Autoantibodies: Association with Infection and Immune Dysregulation |
title_short | Anticytokine Autoantibodies: Association with Infection and Immune Dysregulation |
title_sort | anticytokine autoantibodies: association with infection and immune dysregulation |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6698860/ https://www.ncbi.nlm.nih.gov/pubmed/31557985 http://dx.doi.org/10.3390/antib5010003 |
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