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Anticytokine Autoantibodies: Association with Infection and Immune Dysregulation

The association of autoantibodies to cytokines with immune deficiency, autoimmunity and/or immune dysregulation is increasingly being recognized. For example, autoantibodies to interferon gamma have been found to be associated with chronic, treatment refractory infections with intracellular organism...

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Autores principales: Knight, Vijaya, Merkel, Patricia A., O’Sullivan, Michael D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6698860/
https://www.ncbi.nlm.nih.gov/pubmed/31557985
http://dx.doi.org/10.3390/antib5010003
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author Knight, Vijaya
Merkel, Patricia A.
O’Sullivan, Michael D.
author_facet Knight, Vijaya
Merkel, Patricia A.
O’Sullivan, Michael D.
author_sort Knight, Vijaya
collection PubMed
description The association of autoantibodies to cytokines with immune deficiency, autoimmunity and/or immune dysregulation is increasingly being recognized. For example, autoantibodies to interferon gamma have been found to be associated with chronic, treatment refractory infections with intracellular organisms such as mycobacteria, autoantibodies to interleukin 17 with chronic mucocutaneous candidiasis, and anti-interferon alpha autoantibodies with systemic lupus erythematosus. While low titer autoantibodies to these and other cytokines may be detected in normal individuals, patients with infectious or autoimmune manifestations tend to have high titer autoantibodies that may block or potentiate the function of the respective cytokine. Recognition of these autoantibodies is important because it may direct treatment toward a combination of adjunctive immunotherapy to modulate the autoantibody level while continuing with appropriate anti-microbial therapy. This review focuses on the anti-cytokine autoantibodies documented to date, their autoimmune, immune dysregulation and infectious disease associations, methods for detection of these antibodies and potential treatment options.
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spelling pubmed-66988602019-09-05 Anticytokine Autoantibodies: Association with Infection and Immune Dysregulation Knight, Vijaya Merkel, Patricia A. O’Sullivan, Michael D. Antibodies (Basel) Review The association of autoantibodies to cytokines with immune deficiency, autoimmunity and/or immune dysregulation is increasingly being recognized. For example, autoantibodies to interferon gamma have been found to be associated with chronic, treatment refractory infections with intracellular organisms such as mycobacteria, autoantibodies to interleukin 17 with chronic mucocutaneous candidiasis, and anti-interferon alpha autoantibodies with systemic lupus erythematosus. While low titer autoantibodies to these and other cytokines may be detected in normal individuals, patients with infectious or autoimmune manifestations tend to have high titer autoantibodies that may block or potentiate the function of the respective cytokine. Recognition of these autoantibodies is important because it may direct treatment toward a combination of adjunctive immunotherapy to modulate the autoantibody level while continuing with appropriate anti-microbial therapy. This review focuses on the anti-cytokine autoantibodies documented to date, their autoimmune, immune dysregulation and infectious disease associations, methods for detection of these antibodies and potential treatment options. MDPI 2016-01-15 /pmc/articles/PMC6698860/ /pubmed/31557985 http://dx.doi.org/10.3390/antib5010003 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. https://creativecommons.org/licenses/by/4.0/This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Review
Knight, Vijaya
Merkel, Patricia A.
O’Sullivan, Michael D.
Anticytokine Autoantibodies: Association with Infection and Immune Dysregulation
title Anticytokine Autoantibodies: Association with Infection and Immune Dysregulation
title_full Anticytokine Autoantibodies: Association with Infection and Immune Dysregulation
title_fullStr Anticytokine Autoantibodies: Association with Infection and Immune Dysregulation
title_full_unstemmed Anticytokine Autoantibodies: Association with Infection and Immune Dysregulation
title_short Anticytokine Autoantibodies: Association with Infection and Immune Dysregulation
title_sort anticytokine autoantibodies: association with infection and immune dysregulation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6698860/
https://www.ncbi.nlm.nih.gov/pubmed/31557985
http://dx.doi.org/10.3390/antib5010003
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