Hydrophilic Auristatin Glycoside Payload Enables Improved Antibody-Drug Conjugate Efficacy and Biocompatibility

Antibody-drug conjugates (ADCs) offer a combination of antibody therapy and specific delivery of potent small-molecule payloads to target cells. The properties of the ADC molecule are determined by the balance of its components. The efficacy of the payload component increases with higher drug-to-ant...

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Detalles Bibliográficos
Autores principales: Satomaa, Tero, Pynnönen, Henna, Vilkman, Anja, Kotiranta, Titta, Pitkänen, Virve, Heiskanen, Annamari, Herpers, Bram, Price, Leo S., Helin, Jari, Saarinen, Juhani
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6698876/
https://www.ncbi.nlm.nih.gov/pubmed/31544867
http://dx.doi.org/10.3390/antib7020015

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