ADME Considerations and Bioanalytical Strategies for Pharmacokinetic Assessments of Antibody-Drug Conjugates

Antibody-drug conjugates (ADCs) are a unique class of biotherapeutics of inherent heterogeneity and correspondingly complex absorption, distribution, metabolism, and excretion (ADME) properties. Herein, we consider the contribution of various components of ADCs such as various classes of warheads, l...

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Detalles Bibliográficos
Autores principales: Mou, Si, Huang, Yue, Rosenbaum, Anton I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6698957/
https://www.ncbi.nlm.nih.gov/pubmed/31544891
http://dx.doi.org/10.3390/antib7040041

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6698957/
https://www.ncbi.nlm.nih.gov/pubmed/31544891
http://dx.doi.org/10.3390/antib7040041

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