Enhancers Improve the AID-Induced Hypermutation in Episomal Vector for Antibody Affinity Maturation in Mammalian Cell Display

The induction of somatic hypermutation (SHM) in various cell lines by activation-induced cytidine deaminase (AID) has been used in protein-directed selection, especially in antibody affinity maturation. Several antibody affinity maturation systems based on mammalian cells have been developed in rece...

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Detalles Bibliográficos
Autores principales: Chen, Chuan, Wang, Jie, Zhao, Yun, Chen, Shaopeng, Hu, Zhishang, Chen, Long, Hang, Haiying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6698961/
https://www.ncbi.nlm.nih.gov/pubmed/31544892
http://dx.doi.org/10.3390/antib7040042

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6698961/
https://www.ncbi.nlm.nih.gov/pubmed/31544892
http://dx.doi.org/10.3390/antib7040042

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