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Enhancers Improve the AID-Induced Hypermutation in Episomal Vector for Antibody Affinity Maturation in Mammalian Cell Display

The induction of somatic hypermutation (SHM) in various cell lines by activation-induced cytidine deaminase (AID) has been used in protein-directed selection, especially in antibody affinity maturation. Several antibody affinity maturation systems based on mammalian cells have been developed in rece...

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Detalles Bibliográficos
Autores principales:	Chen, Chuan, Wang, Jie, Zhao, Yun, Chen, Shaopeng, Hu, Zhishang, Chen, Long, Hang, Haiying
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6698961/ https://www.ncbi.nlm.nih.gov/pubmed/31544892 http://dx.doi.org/10.3390/antib7040042

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