Genetic variants of HIF1α are associated with right ventricular fibrotic load in repaired tetralogy of Fallot patients: a cardiovascular magnetic resonance study

BACKGROUND: Studies suggest that right ventricular (RV) fibrosis is associated with RV remodeling and long-term outcomes in patients with tetralogy of Fallot (TOF). Pre-operative hypoxia may increase expression of hypoxia inducible factor-1-alpha (HIF1α) and promote transforming growth factor β1 (TG...

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Autores principales: Hoang, Thanh T., Manso, Paulo Henrique, Edman, Sharon, Mercer-Rosa, Laura, Mitchell, Laura E., Sewda, Anshuman, Swartz, Michael D., Fogel, Mark A., Agopian, A. J., Goldmuntz, Elizabeth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6699069/
https://www.ncbi.nlm.nih.gov/pubmed/31422771
http://dx.doi.org/10.1186/s12968-019-0555-2

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