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Neuroanatomical structures supporting lexical diversity, sophistication, and phonological word features during discourse
Deficits in lexical retrieval are commonly observed in individuals with post-stroke aphasia. Successful lexical retrieval is related to lexical diversity, lexical sophistication, and phonological word properties; however, the crucial brain regions supporting these different features are not fully un...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6699249/ https://www.ncbi.nlm.nih.gov/pubmed/31398554 http://dx.doi.org/10.1016/j.nicl.2019.101961 |
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author | Wilmskoetter, Janina Fridriksson, Julius Gleichgerrcht, Ezequiel Stark, Brielle C. Delgaizo, John Hickok, Gregory Vaden, Kenneth I. Hillis, Argye E. Rorden, Chris Bonilha, Leonardo |
author_facet | Wilmskoetter, Janina Fridriksson, Julius Gleichgerrcht, Ezequiel Stark, Brielle C. Delgaizo, John Hickok, Gregory Vaden, Kenneth I. Hillis, Argye E. Rorden, Chris Bonilha, Leonardo |
author_sort | Wilmskoetter, Janina |
collection | PubMed |
description | Deficits in lexical retrieval are commonly observed in individuals with post-stroke aphasia. Successful lexical retrieval is related to lexical diversity, lexical sophistication, and phonological word properties; however, the crucial brain regions supporting these different features are not fully understood. We performed MRI-based lesion symptom mapping in 58 individuals with a chronic left hemisphere stroke to assess how regional damage relates to spoken discourse-extracted measures of lexical diversity, lexical sophistication, and phonological word properties. For discourse transcription and word feature analysis, we used the Computerized Language Analysis (CLAN) program, Stanford Core Natural Language Processing, Irvine Phonotactic Online Dictionary, Lexical Complexity Analyzer, and Gramulator. Lesions involving the left posterior insula and supramarginal gyri and inferior fronto-occipital fasciculus were significant predictors of utterances with, on average, lower lexical diversity. Low lexical sophistication was associated with damage to the left pole of the superior temporal gyrus. Production of words with lower phonological complexity (fewer phonemes, higher phonological similarity) was associated with damage to the left supramarginal gyrus. Our findings indicate that discourse-extracted features of lexical retrieval depend on the integrity of specific brain regions involving insular and peri-Sylvian areas. The identified regions provide insight into potentially underlying mechanisms of lexically diverse, sophisticated and phonologically complex words produced during discourse. |
format | Online Article Text |
id | pubmed-6699249 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-66992492019-08-22 Neuroanatomical structures supporting lexical diversity, sophistication, and phonological word features during discourse Wilmskoetter, Janina Fridriksson, Julius Gleichgerrcht, Ezequiel Stark, Brielle C. Delgaizo, John Hickok, Gregory Vaden, Kenneth I. Hillis, Argye E. Rorden, Chris Bonilha, Leonardo Neuroimage Clin Regular Article Deficits in lexical retrieval are commonly observed in individuals with post-stroke aphasia. Successful lexical retrieval is related to lexical diversity, lexical sophistication, and phonological word properties; however, the crucial brain regions supporting these different features are not fully understood. We performed MRI-based lesion symptom mapping in 58 individuals with a chronic left hemisphere stroke to assess how regional damage relates to spoken discourse-extracted measures of lexical diversity, lexical sophistication, and phonological word properties. For discourse transcription and word feature analysis, we used the Computerized Language Analysis (CLAN) program, Stanford Core Natural Language Processing, Irvine Phonotactic Online Dictionary, Lexical Complexity Analyzer, and Gramulator. Lesions involving the left posterior insula and supramarginal gyri and inferior fronto-occipital fasciculus were significant predictors of utterances with, on average, lower lexical diversity. Low lexical sophistication was associated with damage to the left pole of the superior temporal gyrus. Production of words with lower phonological complexity (fewer phonemes, higher phonological similarity) was associated with damage to the left supramarginal gyrus. Our findings indicate that discourse-extracted features of lexical retrieval depend on the integrity of specific brain regions involving insular and peri-Sylvian areas. The identified regions provide insight into potentially underlying mechanisms of lexically diverse, sophisticated and phonologically complex words produced during discourse. Elsevier 2019-07-27 /pmc/articles/PMC6699249/ /pubmed/31398554 http://dx.doi.org/10.1016/j.nicl.2019.101961 Text en © 2019 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Regular Article Wilmskoetter, Janina Fridriksson, Julius Gleichgerrcht, Ezequiel Stark, Brielle C. Delgaizo, John Hickok, Gregory Vaden, Kenneth I. Hillis, Argye E. Rorden, Chris Bonilha, Leonardo Neuroanatomical structures supporting lexical diversity, sophistication, and phonological word features during discourse |
title | Neuroanatomical structures supporting lexical diversity, sophistication, and phonological word features during discourse |
title_full | Neuroanatomical structures supporting lexical diversity, sophistication, and phonological word features during discourse |
title_fullStr | Neuroanatomical structures supporting lexical diversity, sophistication, and phonological word features during discourse |
title_full_unstemmed | Neuroanatomical structures supporting lexical diversity, sophistication, and phonological word features during discourse |
title_short | Neuroanatomical structures supporting lexical diversity, sophistication, and phonological word features during discourse |
title_sort | neuroanatomical structures supporting lexical diversity, sophistication, and phonological word features during discourse |
topic | Regular Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6699249/ https://www.ncbi.nlm.nih.gov/pubmed/31398554 http://dx.doi.org/10.1016/j.nicl.2019.101961 |
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