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Neuroanatomical structures supporting lexical diversity, sophistication, and phonological word features during discourse

Deficits in lexical retrieval are commonly observed in individuals with post-stroke aphasia. Successful lexical retrieval is related to lexical diversity, lexical sophistication, and phonological word properties; however, the crucial brain regions supporting these different features are not fully un...

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Autores principales: Wilmskoetter, Janina, Fridriksson, Julius, Gleichgerrcht, Ezequiel, Stark, Brielle C., Delgaizo, John, Hickok, Gregory, Vaden, Kenneth I., Hillis, Argye E., Rorden, Chris, Bonilha, Leonardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6699249/
https://www.ncbi.nlm.nih.gov/pubmed/31398554
http://dx.doi.org/10.1016/j.nicl.2019.101961
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author Wilmskoetter, Janina
Fridriksson, Julius
Gleichgerrcht, Ezequiel
Stark, Brielle C.
Delgaizo, John
Hickok, Gregory
Vaden, Kenneth I.
Hillis, Argye E.
Rorden, Chris
Bonilha, Leonardo
author_facet Wilmskoetter, Janina
Fridriksson, Julius
Gleichgerrcht, Ezequiel
Stark, Brielle C.
Delgaizo, John
Hickok, Gregory
Vaden, Kenneth I.
Hillis, Argye E.
Rorden, Chris
Bonilha, Leonardo
author_sort Wilmskoetter, Janina
collection PubMed
description Deficits in lexical retrieval are commonly observed in individuals with post-stroke aphasia. Successful lexical retrieval is related to lexical diversity, lexical sophistication, and phonological word properties; however, the crucial brain regions supporting these different features are not fully understood. We performed MRI-based lesion symptom mapping in 58 individuals with a chronic left hemisphere stroke to assess how regional damage relates to spoken discourse-extracted measures of lexical diversity, lexical sophistication, and phonological word properties. For discourse transcription and word feature analysis, we used the Computerized Language Analysis (CLAN) program, Stanford Core Natural Language Processing, Irvine Phonotactic Online Dictionary, Lexical Complexity Analyzer, and Gramulator. Lesions involving the left posterior insula and supramarginal gyri and inferior fronto-occipital fasciculus were significant predictors of utterances with, on average, lower lexical diversity. Low lexical sophistication was associated with damage to the left pole of the superior temporal gyrus. Production of words with lower phonological complexity (fewer phonemes, higher phonological similarity) was associated with damage to the left supramarginal gyrus. Our findings indicate that discourse-extracted features of lexical retrieval depend on the integrity of specific brain regions involving insular and peri-Sylvian areas. The identified regions provide insight into potentially underlying mechanisms of lexically diverse, sophisticated and phonologically complex words produced during discourse.
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spelling pubmed-66992492019-08-22 Neuroanatomical structures supporting lexical diversity, sophistication, and phonological word features during discourse Wilmskoetter, Janina Fridriksson, Julius Gleichgerrcht, Ezequiel Stark, Brielle C. Delgaizo, John Hickok, Gregory Vaden, Kenneth I. Hillis, Argye E. Rorden, Chris Bonilha, Leonardo Neuroimage Clin Regular Article Deficits in lexical retrieval are commonly observed in individuals with post-stroke aphasia. Successful lexical retrieval is related to lexical diversity, lexical sophistication, and phonological word properties; however, the crucial brain regions supporting these different features are not fully understood. We performed MRI-based lesion symptom mapping in 58 individuals with a chronic left hemisphere stroke to assess how regional damage relates to spoken discourse-extracted measures of lexical diversity, lexical sophistication, and phonological word properties. For discourse transcription and word feature analysis, we used the Computerized Language Analysis (CLAN) program, Stanford Core Natural Language Processing, Irvine Phonotactic Online Dictionary, Lexical Complexity Analyzer, and Gramulator. Lesions involving the left posterior insula and supramarginal gyri and inferior fronto-occipital fasciculus were significant predictors of utterances with, on average, lower lexical diversity. Low lexical sophistication was associated with damage to the left pole of the superior temporal gyrus. Production of words with lower phonological complexity (fewer phonemes, higher phonological similarity) was associated with damage to the left supramarginal gyrus. Our findings indicate that discourse-extracted features of lexical retrieval depend on the integrity of specific brain regions involving insular and peri-Sylvian areas. The identified regions provide insight into potentially underlying mechanisms of lexically diverse, sophisticated and phonologically complex words produced during discourse. Elsevier 2019-07-27 /pmc/articles/PMC6699249/ /pubmed/31398554 http://dx.doi.org/10.1016/j.nicl.2019.101961 Text en © 2019 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Regular Article
Wilmskoetter, Janina
Fridriksson, Julius
Gleichgerrcht, Ezequiel
Stark, Brielle C.
Delgaizo, John
Hickok, Gregory
Vaden, Kenneth I.
Hillis, Argye E.
Rorden, Chris
Bonilha, Leonardo
Neuroanatomical structures supporting lexical diversity, sophistication, and phonological word features during discourse
title Neuroanatomical structures supporting lexical diversity, sophistication, and phonological word features during discourse
title_full Neuroanatomical structures supporting lexical diversity, sophistication, and phonological word features during discourse
title_fullStr Neuroanatomical structures supporting lexical diversity, sophistication, and phonological word features during discourse
title_full_unstemmed Neuroanatomical structures supporting lexical diversity, sophistication, and phonological word features during discourse
title_short Neuroanatomical structures supporting lexical diversity, sophistication, and phonological word features during discourse
title_sort neuroanatomical structures supporting lexical diversity, sophistication, and phonological word features during discourse
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6699249/
https://www.ncbi.nlm.nih.gov/pubmed/31398554
http://dx.doi.org/10.1016/j.nicl.2019.101961
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