Palmitic acid-induced lipotoxicity promotes a novel interplay between Akt-mTOR, IRS-1, and FFAR1 signaling in pancreatic β-cells

BACKGROUND: Free fatty acid receptor 1 (FFAR1) is G-protein coupled receptor predominantly expressed in pancreatic β-cells that is activated by a variety of free fatty acids (FFAs). Once activated, it promotes glucose-stimulated insulin secretion (GSIS). However, increased levels of FFAs lead to lip...

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Detalles Bibliográficos
Autores principales: Marafie, Sulaiman K., Al-Shawaf, Eman M., Abubaker, Jehad, Arefanian, Hossein
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6699284/
https://www.ncbi.nlm.nih.gov/pubmed/31426858
http://dx.doi.org/10.1186/s40659-019-0253-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6699284/
https://www.ncbi.nlm.nih.gov/pubmed/31426858
http://dx.doi.org/10.1186/s40659-019-0253-4

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