Cargando…

Palmitic acid-induced lipotoxicity promotes a novel interplay between Akt-mTOR, IRS-1, and FFAR1 signaling in pancreatic β-cells

BACKGROUND: Free fatty acid receptor 1 (FFAR1) is G-protein coupled receptor predominantly expressed in pancreatic β-cells that is activated by a variety of free fatty acids (FFAs). Once activated, it promotes glucose-stimulated insulin secretion (GSIS). However, increased levels of FFAs lead to lip...

Descripción completa

Detalles Bibliográficos
Autores principales:	Marafie, Sulaiman K., Al-Shawaf, Eman M., Abubaker, Jehad, Arefanian, Hossein
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6699284/ https://www.ncbi.nlm.nih.gov/pubmed/31426858 http://dx.doi.org/10.1186/s40659-019-0253-4

Ejemplares similares

Targeting SARS-CoV-2 Macrodomain-1 to Restore the Innate Immune Response Using In Silico Screening of Medicinal Compounds and Free Energy Calculation Approaches
por: Mohammad, Anwar, et al.
Publicado: (2023)

Butyrate dictates ferroptosis sensitivity through FFAR2-mTOR signaling
por: Wang, GuoYan, et al.
Publicado: (2023)

Discovery of natural products to block SARS-CoV-2 S-protein interaction with Neuropilin-1 receptor: A molecular dynamics simulation approach
por: Alshawaf, Eman, et al.
Publicado: (2022)

mTOR Modulation of I(Kr) through hERG1b-Dependent Mechanisms in Lipotoxic Heart
por: Aromolaran, Kelly A., et al.
Publicado: (2022)

Lipotoxicity of Palmitic Acid on Neural Progenitor Cells and Hippocampal Neurogenesis
por: Park, Hee Ra, et al.
Publicado: (2011)

Lysosomal Ca(2+) as a mediator of palmitate-induced lipotoxicity
por: Oh, Soo-Jin, et al.
Publicado: (2023)

Basal hypersecretion of glucagon and insulin from palmitate-exposed human islets depends on FFAR1 but not decreased somatostatin secretion
por: Kristinsson, H., et al.
Publicado: (2017)

Higher binding affinity of furin for SARS-CoV-2 spike (S) protein D614G mutant could be associated with higher SARS-CoV-2 infectivity
por: Mohammad, Anwar, et al.
Publicado: (2021)

Structural analysis of ACE2 variant N720D demonstrates a higher binding affinity to TMPRSS2
por: Mohammad, Anwar, et al.
Publicado: (2020)

Molecular Simulation-Based Investigation of Highly Potent Natural Products to Abrogate Formation of the nsp10–nsp16 Complex of SARS-CoV-2
por: Mohammad, Anwar, et al.
Publicado: (2021)

Canagliflozin attenuates lipotoxicity in cardiomyocytes and protects diabetic mouse hearts by inhibiting the mTOR/HIF-1α pathway
por: Sun, Pengbo, et al.
Publicado: (2021)

The TLR4‐IRE1α pathway activation contributes to palmitate‐elicited lipotoxicity in hepatocytes
por: Shen, Chen, et al.
Publicado: (2018)

Protopanaxadiol ameliorates palmitate-induced lipotoxicity and pancreatic β-cell dysfunction in INS-1 cells
por: Lee, Dahae, et al.
Publicado: (2023)

Palmitic Acid Lipotoxicity in Microglia Cells Is Ameliorated by Unsaturated Fatty Acids
por: Urso, C.J., et al.
Publicado: (2021)

Increased glycolysis is an early consequence of palmitate lipotoxicity mediated by redox signaling
por: Kakimoto, Pamela A., et al.
Publicado: (2021)

Baicalein protects rat insulinoma INS-1 cells from palmitate-induced lipotoxicity by inducing HO-1
por: Kwak, Hyun Jeong, et al.
Publicado: (2017)

Inhibition of ghrelin o-acyltransferase attenuated lipotoxicity by inducing autophagy via AMPK–mTOR pathway
por: Zhang, Shaoren, et al.
Publicado: (2018)

Atherogenic Index of Plasma (AIP) a Tool to Assess Changes in Cardiovascular Disease Risk Post Laparoscopic Sleeve Gastrectomy
por: Al Shawaf, Eman, et al.
Publicado: (2020)

The Paradox of Akt-mTOR Interactions
por: Vadlakonda, Lakshmipathi, et al.
Publicado: (2013)

Regulation of Osteoclast Growth and Fusion by mTOR/raptor and mTOR/rictor/Akt
por: Tiedemann, Kerstin, et al.
Publicado: (2017)

Expression of FFAR3 and FFAR4 Is Increased in Gastroesophageal Reflux Disease
por: Fabisiak, Adam, et al.
Publicado: (2020)

Mechanistic Studies on the Stereoselectivity of FFAR1 Modulators
por: Teng, Dan, et al.
Publicado: (2022)

Exploring the Binding Mechanism of NRG1–ERBB3 Complex and Discovery of Potent Natural Products to Reduce Diabetes-Assisted Breast Cancer Progression
por: Marafie, Sulaiman K., et al.
Publicado: (2023)

Optimization of First-in-Class Dual-Acting FFAR1/FFAR4 Allosteric Modulators with Novel Mode of Action
por: Lückmann, Michael, et al.
Publicado: (2022)

Protection of palmitic acid-mediated lipotoxicity by arachidonic acid via channeling of palmitic acid into triglycerides in C2C12
por: Cheon, Hyae Gyeong, et al.
Publicado: (2014)

Mechanism of GLP-1 Receptor Agonists-Mediated Attenuation of Palmitic Acid-Induced Lipotoxicity in L6 Myoblasts
por: Kong, Mo-wei, et al.
Publicado: (2022)

Role of CD36 in Palmitic Acid Lipotoxicity in Neuro-2a Neuroblastoma Cells
por: Urso, C. J., et al.
Publicado: (2021)

Palmitate lipotoxicity is closely associated with the fatty acid-albumin complexes in BV-2 microglia
por: Yang, Yanzhuo, et al.
Publicado: (2023)

PLD1 regulates adipogenic differentiation through mTOR - IRS-1 phosphorylation at serine 636/639
por: Song, Hae-In, et al.
Publicado: (2016)

Molecular mechanism of fatty acid activation of FFAR1
por: Kumari, Punita, et al.
Publicado: (2023)

Kidney Injury Molecule-1 Is Upregulated in Renal Lipotoxicity and Mediates Palmitate-Induced Tubular Cell Injury and Inflammatory Response
por: Zhao, Xueying, et al.
Publicado: (2019)

Tranilast protects pancreatic β-cells from palmitic acid-induced lipotoxicity via FoxO-1 inhibition
por: Choi, Hye-Eun, et al.
Publicado: (2023)

Involvement of Akt-1 and mTOR in Sensitivity of Breast Cancer to Targeted Therapy
por: Sokolosky, Melissa L., et al.
Publicado: (2011)

Akt1 Enhances CA916798 Expression through mTOR Pathway
por: Wang, Yu-Liang, et al.
Publicado: (2013)

SIL1 functions as an oncogene in glioma by AKT/mTOR signaling pathway
por: Xu, Hao, et al.
Publicado: (2018)

Aldose reductase interacts with AKT1 to augment hepatic AKT/mTOR signaling and promote hepatocarcinogenesis
por: Zhao, Jia-Xing, et al.
Publicado: (2017)

ER calcium release promotes mitochondrial dysfunction and hepatic cell lipotoxicity in response to palmitate overload
por: Egnatchik, Robert A., et al.
Publicado: (2014)

Cytoprotective Effect of Hispidin against Palmitate-Induced Lipotoxicity in C2C12 Myotubes
por: Park, Jun Myoung, et al.
Publicado: (2015)

Oleic acid ameliorates palmitic acid induced hepatocellular lipotoxicity by inhibition of ER stress and pyroptosis
por: Zeng, Xin, et al.
Publicado: (2020)

Quercetin and Its Derivative Counteract Palmitate-Dependent Lipotoxicity by Inhibiting Oxidative Stress and Inflammation in Cardiomyocytes
por: Granieri, Maria Concetta, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_6s36shfa1p5qa02gain360rdva