First-in-human in vivo non-invasive assessment of intra-tumoral metabolic heterogeneity in renal cell carcinoma

Intratumoral genetic heterogeneity and the role of metabolic reprogramming in renal cell carcinoma have been extensively documented. However, the distribution of these metabolic changes within the tissue has not been explored. We report on the first-in-human in vivo non-invasive metabolic interrogat...

Descripción completa

Detalles Bibliográficos
Autores principales: Tran, Maxine, Latifoltojar, Arash, Neves, Joana B., Papoutsaki, Marianthi-Vasiliki, Gong, Fiona, Comment, Arnaud, Costa, Ana S. H., Glaser, Matthias, Tran-Dang, My-Anh, El Sheikh, Soha, Piga, Wivijin, Bainbridge, Alan, Barnes, Anna, Young, Tim, Jeraj, Hassan, Awais, Ramla, Adeleke, Sola, Holt, Christopher, O’Callaghan, James, Twyman, Frazer, Atkinson, David, Frezza, Christian, Årstad, Erik, Gadian, David, Emberton, Mark, Punwani, Shonit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The British Institute of Radiology. 2019
Materias:
Technical Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6699984/
https://www.ncbi.nlm.nih.gov/pubmed/31428445
http://dx.doi.org/10.1259/bjrcr.20190003
Descripción
Sumario:Intratumoral genetic heterogeneity and the role of metabolic reprogramming in renal cell carcinoma have been extensively documented. However, the distribution of these metabolic changes within the tissue has not been explored. We report on the first-in-human in vivo non-invasive metabolic interrogation of renal cell carcinoma using hyperpolarized carbon-13 ((13)C) MRI and describe the validation of in vivo lactate metabolic heterogeneity against multi regional ex vivo mass spectrometry. hyperpolarized carbon-13 ((13)C)-MRI provides an in vivo assessment of metabolism and provides a novel opportunity to safely and non-invasively assess cancer heterogeneity.

Ejemplares similares