First-in-human in vivo non-invasive assessment of intra-tumoral metabolic heterogeneity in renal cell carcinoma

Intratumoral genetic heterogeneity and the role of metabolic reprogramming in renal cell carcinoma have been extensively documented. However, the distribution of these metabolic changes within the tissue has not been explored. We report on the first-in-human in vivo non-invasive metabolic interrogat...

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Autores principales: Tran, Maxine, Latifoltojar, Arash, Neves, Joana B., Papoutsaki, Marianthi-Vasiliki, Gong, Fiona, Comment, Arnaud, Costa, Ana S. H., Glaser, Matthias, Tran-Dang, My-Anh, El Sheikh, Soha, Piga, Wivijin, Bainbridge, Alan, Barnes, Anna, Young, Tim, Jeraj, Hassan, Awais, Ramla, Adeleke, Sola, Holt, Christopher, O’Callaghan, James, Twyman, Frazer, Atkinson, David, Frezza, Christian, Årstad, Erik, Gadian, David, Emberton, Mark, Punwani, Shonit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The British Institute of Radiology. 2019
Materias:
Technical Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6699984/
https://www.ncbi.nlm.nih.gov/pubmed/31428445
http://dx.doi.org/10.1259/bjrcr.20190003
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author Tran, Maxine
Latifoltojar, Arash
Neves, Joana B.
Papoutsaki, Marianthi-Vasiliki
Gong, Fiona
Comment, Arnaud
Costa, Ana S. H.
Glaser, Matthias
Tran-Dang, My-Anh
El Sheikh, Soha
Piga, Wivijin
Bainbridge, Alan
Barnes, Anna
Young, Tim
Jeraj, Hassan
Awais, Ramla
Adeleke, Sola
Holt, Christopher
O’Callaghan, James
Twyman, Frazer
Atkinson, David
Frezza, Christian
Årstad, Erik
Gadian, David
Emberton, Mark
Punwani, Shonit
author_facet Tran, Maxine
Latifoltojar, Arash
Neves, Joana B.
Papoutsaki, Marianthi-Vasiliki
Gong, Fiona
Comment, Arnaud
Costa, Ana S. H.
Glaser, Matthias
Tran-Dang, My-Anh
El Sheikh, Soha
Piga, Wivijin
Bainbridge, Alan
Barnes, Anna
Young, Tim
Jeraj, Hassan
Awais, Ramla
Adeleke, Sola
Holt, Christopher
O’Callaghan, James
Twyman, Frazer
Atkinson, David
Frezza, Christian
Årstad, Erik
Gadian, David
Emberton, Mark
Punwani, Shonit
author_sort Tran, Maxine
collection PubMed
description Intratumoral genetic heterogeneity and the role of metabolic reprogramming in renal cell carcinoma have been extensively documented. However, the distribution of these metabolic changes within the tissue has not been explored. We report on the first-in-human in vivo non-invasive metabolic interrogation of renal cell carcinoma using hyperpolarized carbon-13 ((13)C) MRI and describe the validation of in vivo lactate metabolic heterogeneity against multi regional ex vivo mass spectrometry. hyperpolarized carbon-13 ((13)C)-MRI provides an in vivo assessment of metabolism and provides a novel opportunity to safely and non-invasively assess cancer heterogeneity.
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spelling pubmed-66999842019-08-19 First-in-human in vivo non-invasive assessment of intra-tumoral metabolic heterogeneity in renal cell carcinoma Tran, Maxine Latifoltojar, Arash Neves, Joana B. Papoutsaki, Marianthi-Vasiliki Gong, Fiona Comment, Arnaud Costa, Ana S. H. Glaser, Matthias Tran-Dang, My-Anh El Sheikh, Soha Piga, Wivijin Bainbridge, Alan Barnes, Anna Young, Tim Jeraj, Hassan Awais, Ramla Adeleke, Sola Holt, Christopher O’Callaghan, James Twyman, Frazer Atkinson, David Frezza, Christian Årstad, Erik Gadian, David Emberton, Mark Punwani, Shonit BJR Case Rep Technical Note Intratumoral genetic heterogeneity and the role of metabolic reprogramming in renal cell carcinoma have been extensively documented. However, the distribution of these metabolic changes within the tissue has not been explored. We report on the first-in-human in vivo non-invasive metabolic interrogation of renal cell carcinoma using hyperpolarized carbon-13 ((13)C) MRI and describe the validation of in vivo lactate metabolic heterogeneity against multi regional ex vivo mass spectrometry. hyperpolarized carbon-13 ((13)C)-MRI provides an in vivo assessment of metabolism and provides a novel opportunity to safely and non-invasively assess cancer heterogeneity. The British Institute of Radiology. 2019-03-04 /pmc/articles/PMC6699984/ /pubmed/31428445 http://dx.doi.org/10.1259/bjrcr.20190003 Text en © 2019 The Authors. Published by the British Institute of Radiology This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.
spellingShingle Technical Note
Tran, Maxine
Latifoltojar, Arash
Neves, Joana B.
Papoutsaki, Marianthi-Vasiliki
Gong, Fiona
Comment, Arnaud
Costa, Ana S. H.
Glaser, Matthias
Tran-Dang, My-Anh
El Sheikh, Soha
Piga, Wivijin
Bainbridge, Alan
Barnes, Anna
Young, Tim
Jeraj, Hassan
Awais, Ramla
Adeleke, Sola
Holt, Christopher
O’Callaghan, James
Twyman, Frazer
Atkinson, David
Frezza, Christian
Årstad, Erik
Gadian, David
Emberton, Mark
Punwani, Shonit
First-in-human in vivo non-invasive assessment of intra-tumoral metabolic heterogeneity in renal cell carcinoma
title First-in-human in vivo non-invasive assessment of intra-tumoral metabolic heterogeneity in renal cell carcinoma
title_full First-in-human in vivo non-invasive assessment of intra-tumoral metabolic heterogeneity in renal cell carcinoma
title_fullStr First-in-human in vivo non-invasive assessment of intra-tumoral metabolic heterogeneity in renal cell carcinoma
title_full_unstemmed First-in-human in vivo non-invasive assessment of intra-tumoral metabolic heterogeneity in renal cell carcinoma
title_short First-in-human in vivo non-invasive assessment of intra-tumoral metabolic heterogeneity in renal cell carcinoma
title_sort first-in-human in vivo non-invasive assessment of intra-tumoral metabolic heterogeneity in renal cell carcinoma
topic Technical Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6699984/
https://www.ncbi.nlm.nih.gov/pubmed/31428445
http://dx.doi.org/10.1259/bjrcr.20190003
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