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Serum Vitamin D Level Does not Affect The Sensitivity of Parathyroid Adenoma Localization Tests

The aim of the present study was to evaluate the predictive value of 25-hydroxyvitamin D, calcium and parathormone level, co-existence of thyroid nodule, thyroidectomy history and adenoma volume on the success of neck ultrasound (US) and technetium-99m sestamibi (MIBI) scan in primary hyperparathyro...

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Autores principales: Sencar, Muhammed Erkam, Sakiz, Davut, Unsal, Ilknur Ozturk, Hepsen, Sema, Calapkulu, Murat, Gumus, Pelin, Ucan, Bekir, Ozbek, Mustafa, Cakal, Erman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6700071/
https://www.ncbi.nlm.nih.gov/pubmed/31427650
http://dx.doi.org/10.1038/s41598-019-48536-z
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author Sencar, Muhammed Erkam
Sakiz, Davut
Unsal, Ilknur Ozturk
Hepsen, Sema
Calapkulu, Murat
Gumus, Pelin
Ucan, Bekir
Ozbek, Mustafa
Cakal, Erman
author_facet Sencar, Muhammed Erkam
Sakiz, Davut
Unsal, Ilknur Ozturk
Hepsen, Sema
Calapkulu, Murat
Gumus, Pelin
Ucan, Bekir
Ozbek, Mustafa
Cakal, Erman
author_sort Sencar, Muhammed Erkam
collection PubMed
description The aim of the present study was to evaluate the predictive value of 25-hydroxyvitamin D, calcium and parathormone level, co-existence of thyroid nodule, thyroidectomy history and adenoma volume on the success of neck ultrasound (US) and technetium-99m sestamibi (MIBI) scan in primary hyperparathyroidism (PHP) patients. This study included 256 patients with PHP who underwent parathyroidectomy. 169 (%66) patients had vitamin D deficiency and 56 (%22) of patients had insufficiency. The sensitivity of US and MIBI studies showed no difference between vitamin D deficiency, insufficiency and replete groups (%80.5, %82 and %71 (p > 0.05) and %81, %84 and %71 respectively (p > 0.05)). Vitamin D level was not found to be an independent predictor of localization on either US or MIBI scan after adjusting for different variables (p > 0.05). Calcium level was found to be an independent predictor for US sensitivity (r(2):0,033, p:0,032) and parathormone level for MIBI sensitivity (r(2):0,05, p:0,025). The co-existence of nodular thyroid disease and history of thyroidectomy significantly decreased the sensitivity of US (%76 and %43). MIBI sensitivity was not impaired by nodular disease but the history of thyroidectomy also impaired the sensitivity of MIBI (%43). As a result vitamin D level does not affect the sensitivity of preoperative localization tests.
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spelling pubmed-67000712019-08-21 Serum Vitamin D Level Does not Affect The Sensitivity of Parathyroid Adenoma Localization Tests Sencar, Muhammed Erkam Sakiz, Davut Unsal, Ilknur Ozturk Hepsen, Sema Calapkulu, Murat Gumus, Pelin Ucan, Bekir Ozbek, Mustafa Cakal, Erman Sci Rep Article The aim of the present study was to evaluate the predictive value of 25-hydroxyvitamin D, calcium and parathormone level, co-existence of thyroid nodule, thyroidectomy history and adenoma volume on the success of neck ultrasound (US) and technetium-99m sestamibi (MIBI) scan in primary hyperparathyroidism (PHP) patients. This study included 256 patients with PHP who underwent parathyroidectomy. 169 (%66) patients had vitamin D deficiency and 56 (%22) of patients had insufficiency. The sensitivity of US and MIBI studies showed no difference between vitamin D deficiency, insufficiency and replete groups (%80.5, %82 and %71 (p > 0.05) and %81, %84 and %71 respectively (p > 0.05)). Vitamin D level was not found to be an independent predictor of localization on either US or MIBI scan after adjusting for different variables (p > 0.05). Calcium level was found to be an independent predictor for US sensitivity (r(2):0,033, p:0,032) and parathormone level for MIBI sensitivity (r(2):0,05, p:0,025). The co-existence of nodular thyroid disease and history of thyroidectomy significantly decreased the sensitivity of US (%76 and %43). MIBI sensitivity was not impaired by nodular disease but the history of thyroidectomy also impaired the sensitivity of MIBI (%43). As a result vitamin D level does not affect the sensitivity of preoperative localization tests. Nature Publishing Group UK 2019-08-19 /pmc/articles/PMC6700071/ /pubmed/31427650 http://dx.doi.org/10.1038/s41598-019-48536-z Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Sencar, Muhammed Erkam
Sakiz, Davut
Unsal, Ilknur Ozturk
Hepsen, Sema
Calapkulu, Murat
Gumus, Pelin
Ucan, Bekir
Ozbek, Mustafa
Cakal, Erman
Serum Vitamin D Level Does not Affect The Sensitivity of Parathyroid Adenoma Localization Tests
title Serum Vitamin D Level Does not Affect The Sensitivity of Parathyroid Adenoma Localization Tests
title_full Serum Vitamin D Level Does not Affect The Sensitivity of Parathyroid Adenoma Localization Tests
title_fullStr Serum Vitamin D Level Does not Affect The Sensitivity of Parathyroid Adenoma Localization Tests
title_full_unstemmed Serum Vitamin D Level Does not Affect The Sensitivity of Parathyroid Adenoma Localization Tests
title_short Serum Vitamin D Level Does not Affect The Sensitivity of Parathyroid Adenoma Localization Tests
title_sort serum vitamin d level does not affect the sensitivity of parathyroid adenoma localization tests
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6700071/
https://www.ncbi.nlm.nih.gov/pubmed/31427650
http://dx.doi.org/10.1038/s41598-019-48536-z
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