Regulating autophagy facilitated therapeutic efficacy of the sonic Hedgehog pathway inhibition on lung adenocarcinoma through GLI2 suppression and ROS production

Lung adenocarcinoma (LUAD), which comprises over 50% of all cases of non-small-cell lung cancer, has a poor prognosis and requires novel therapeutic approaches. The sonic Hedgehog (Shh) pathway, which plays a crucial role in differentiation, proliferation, and survival of cancer cells, is likely to...

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Detalles Bibliográficos
Autores principales: Fan, Jiajun, Zhang, Xuyao, Wang, Shaofei, Chen, Wei, Li, Yubin, Zeng, Xian, Wang, Yichen, Luan, Jingyun, Li, Li, Wang, Ziyu, Sun, Xilin, Shen, Baozhong, Ju, Dianwen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6700102/
https://www.ncbi.nlm.nih.gov/pubmed/31427566
http://dx.doi.org/10.1038/s41419-019-1840-6

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