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Regular exercise improves asthma control in adults: A randomized controlled trial

We conducted a randomized controlled trial to test the hypothesis that a 24-week exercise intervention improves asthma control in adults. Adults with mild or moderate asthma were randomly assigned to either the exercise intervention group (IG) or the reference group (RG). Participants in IG received...

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Autores principales: Jaakkola, Jouni J. K., Aalto, Sirpa A. M., Hernberg, Samu, Kiihamäki, Simo-Pekka, Jaakkola, Maritta S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6700123/
https://www.ncbi.nlm.nih.gov/pubmed/31427628
http://dx.doi.org/10.1038/s41598-019-48484-8
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author Jaakkola, Jouni J. K.
Aalto, Sirpa A. M.
Hernberg, Samu
Kiihamäki, Simo-Pekka
Jaakkola, Maritta S.
author_facet Jaakkola, Jouni J. K.
Aalto, Sirpa A. M.
Hernberg, Samu
Kiihamäki, Simo-Pekka
Jaakkola, Maritta S.
author_sort Jaakkola, Jouni J. K.
collection PubMed
description We conducted a randomized controlled trial to test the hypothesis that a 24-week exercise intervention improves asthma control in adults. Adults with mild or moderate asthma were randomly assigned to either the exercise intervention group (IG) or the reference group (RG). Participants in IG received an individualized exercising program, including aerobic exercise at least three times a week for ≥30 minutes, muscle training, and stretching. The primary outcome was asthma control, measured by Asthma Control Test (ACT), asthma-related symptoms, and peak expiratory flow (PEF) variability. We estimated the risk (i.e. probability) of improvement in asthma control and the risk difference (RD) between IG and RG. Of 131 subjects (67 IG/64 RG) entered, 105 subjects (51/54) completed the trial (80%), and 89 (44/45) were analysed (68%). The ACT became better among 26 (62%) participants in IG and among 17 (39%) participants in RG. The effect of intervention on improving asthma control was 23% (RD = 0.23, 95% CI 0.027–0.438; P = 0.0320). The intervention also reduced shortness of breath by 30.1% (RD = 0.301, 95% CI 0.109–0.492; P = 0.003). The change in PEF variability was similar in both groups. Regular exercise improves asthma control measured by the ACT, while has little effect on PEF variability.
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spelling pubmed-67001232019-08-21 Regular exercise improves asthma control in adults: A randomized controlled trial Jaakkola, Jouni J. K. Aalto, Sirpa A. M. Hernberg, Samu Kiihamäki, Simo-Pekka Jaakkola, Maritta S. Sci Rep Article We conducted a randomized controlled trial to test the hypothesis that a 24-week exercise intervention improves asthma control in adults. Adults with mild or moderate asthma were randomly assigned to either the exercise intervention group (IG) or the reference group (RG). Participants in IG received an individualized exercising program, including aerobic exercise at least three times a week for ≥30 minutes, muscle training, and stretching. The primary outcome was asthma control, measured by Asthma Control Test (ACT), asthma-related symptoms, and peak expiratory flow (PEF) variability. We estimated the risk (i.e. probability) of improvement in asthma control and the risk difference (RD) between IG and RG. Of 131 subjects (67 IG/64 RG) entered, 105 subjects (51/54) completed the trial (80%), and 89 (44/45) were analysed (68%). The ACT became better among 26 (62%) participants in IG and among 17 (39%) participants in RG. The effect of intervention on improving asthma control was 23% (RD = 0.23, 95% CI 0.027–0.438; P = 0.0320). The intervention also reduced shortness of breath by 30.1% (RD = 0.301, 95% CI 0.109–0.492; P = 0.003). The change in PEF variability was similar in both groups. Regular exercise improves asthma control measured by the ACT, while has little effect on PEF variability. Nature Publishing Group UK 2019-08-19 /pmc/articles/PMC6700123/ /pubmed/31427628 http://dx.doi.org/10.1038/s41598-019-48484-8 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Jaakkola, Jouni J. K.
Aalto, Sirpa A. M.
Hernberg, Samu
Kiihamäki, Simo-Pekka
Jaakkola, Maritta S.
Regular exercise improves asthma control in adults: A randomized controlled trial
title Regular exercise improves asthma control in adults: A randomized controlled trial
title_full Regular exercise improves asthma control in adults: A randomized controlled trial
title_fullStr Regular exercise improves asthma control in adults: A randomized controlled trial
title_full_unstemmed Regular exercise improves asthma control in adults: A randomized controlled trial
title_short Regular exercise improves asthma control in adults: A randomized controlled trial
title_sort regular exercise improves asthma control in adults: a randomized controlled trial
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6700123/
https://www.ncbi.nlm.nih.gov/pubmed/31427628
http://dx.doi.org/10.1038/s41598-019-48484-8
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