Blockade of α4 integrins reduces leukocyte–endothelial interactions in cerebral vessels and improves memory in a mouse model of Alzheimer’s disease

Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by cognitive decline associated with the deposition of amyloid-β (Aβ) plaques, hyperphosphorylation of tau protein, and neuronal loss. Vascular inflammation and leukocyte trafficking may contribute to AD pathogenesis, and a bette...

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Detalles Bibliográficos
Autores principales: Pietronigro, Enrica, Zenaro, Elena, Bianca, Vittorina Della, Dusi, Silvia, Terrabuio, Eleonora, Iannoto, Giulia, Slanzi, Anna, Ghasemi, Somayehsadat, Nagarajan, Rajasekar, Piacentino, Gennj, Tosadori, Gabriele, Rossi, Barbara, Constantin, Gabriela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6700124/
https://www.ncbi.nlm.nih.gov/pubmed/31427644
http://dx.doi.org/10.1038/s41598-019-48538-x

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