Cargando…

AAV-ie enables safe and efficient gene transfer to inner ear cells

Hearing loss is the most common sensory disorder. While gene therapy has emerged as a promising treatment of inherited diseases like hearing loss, it is dependent on the identification of gene delivery vectors. Adeno-associated virus (AAV) vector-mediated gene therapy has been approved in the US for...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tan, Fangzhi, Chu, Cenfeng, Qi, Jieyu, Li, Wenyan, You, Dan, Li, Ke, Chen, Xin, Zhao, Weidong, Cheng, Cheng, Liu, Xiaoyi, Qiao, Yunbo, Su, Bing, He, Shuijin, Zhong, Chao, Li, Huawei, Chai, Renjie, Zhong, Guisheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6700137/ https://www.ncbi.nlm.nih.gov/pubmed/31427575 http://dx.doi.org/10.1038/s41467-019-11687-8

Ejemplares similares

AAV-ie-K558R mediated cochlear gene therapy and hair cell regeneration
por: Tao, Yong, et al.
Publicado: (2022)

A cytoskeleton structure revealed by super-resolution fluorescence imaging in inner ear hair cells
por: Qi, Jieyu, et al.
Publicado: (2019)

Recent development of AAV-based gene therapies for inner ear disorders
por: Lan, Yiyang, et al.
Publicado: (2020)

Histone deacetylase 1 is required for the development of the zebrafish inner ear
por: He, Yingzi, et al.
Publicado: (2016)

Correction: Recent development of AAV-based gene therapies for inner ear disorders
por: Lan, Yiyang, et al.
Publicado: (2020)

Critical role of spectrin in hearing development and deafness
por: Liu, Yan, et al.
Publicado: (2019)

Single-Cell Sequencing Applications in the Inner Ear
por: Wu, Mingxuan, et al.
Publicado: (2021)

A synthetic AAV vector enables safe and efficient gene transfer to the mammalian inner ear
por: Landegger, Lukas D., et al.
Publicado: (2017)

IE-Map: a novel in-vivo atlas and template of the human inner ear
por: Ahmadi, Seyed-Ahmad, et al.
Publicado: (2021)

IE-Vnet: Deep Learning-Based Segmentation of the Inner Ear's Total Fluid Space
por: Ahmadi, Seyed-Ahmad, et al.
Publicado: (2022)

AAV-ie-mediated UCP2 overexpression accelerates inner hair cell loss during aging in vivo
por: Zhao, Chunli, et al.
Publicado: (2022)

A protective AAV vaccine for SARS-CoV-2
por: Zhao, Simeng, et al.
Publicado: (2022)

AAV-S: A versatile capsid variant for transduction of mouse and primate inner ear
por: Ivanchenko, Maryna V., et al.
Publicado: (2021)

The Role of FoxG1 in the Inner Ear
por: Ding, Yanyan, et al.
Publicado: (2020)

MiR-182-5p protects inner ear hair cells from cisplatin-induced apoptosis by inhibiting FOXO3a
por: Li, Yimeng, et al.
Publicado: (2016)

Rps14 upregulation promotes inner ear progenitor proliferation and hair cell regeneration in the neonatal mouse cochlea
por: Xu, Changling, et al.
Publicado: (2023)

Activation of the RhoA‐YAP‐β‐catenin signaling axis promotes the expansion of inner ear progenitor cells in 3D culture
por: Xia, Mingyu, et al.
Publicado: (2020)

Disrupting the Interaction between Retinoblastoma Protein and Raf-1 Leads to Defects in Progenitor Cell Proliferation and Survival during Early Inner Ear Development
por: Li, Wenyan, et al.
Publicado: (2013)

Graphene Substrates Promote the Differentiation of Inner Ear Lgr5+ Progenitor Cells Into Hair Cells
por: Ding, Xiaoqiong, et al.
Publicado: (2022)

AAV2.7m8 is a powerful viral vector for inner ear gene therapy
por: Isgrig, Kevin, et al.
Publicado: (2019)

BMP4 signaling is involved in the generation of inner ear sensory epithelia
por: Li, Huawei, et al.
Publicado: (2005)

Inner Ear
por: Arnold, Andreas, et al.
Publicado: (2010)

Efficient Viral Transduction in Fetal and Adult Human Inner Ear Explants with AAV9-PHP.B Vectors
por: van Beelen, Edward S. A., et al.
Publicado: (2022)

Adenovirus Vectors Target Several Cell Subtypes of Mammalian Inner Ear In Vivo
por: Shu, Yilai, et al.
Publicado: (2016)

Combined use of microbubbles of various sizes and single‐transducer dual‐frequency ultrasound for safe and efficient inner ear drug delivery
por: Liao, Ai‐Ho, et al.
Publicado: (2022)

Protective effect of adenovirus-mediated erythropoietin expression on the spiral ganglion neurons in the rat inner ear
por: Zhong, Cheng, et al.
Publicado: (2018)

Proteomics and the Inner Ear
por: Thalmann, Isolde
Publicado: (2001)

Role of Cyclic Nucleotide Phosphodiesterases in Inner Ear and Hearing
por: Mittal, Rahul, et al.
Publicado: (2017)

Inner Ear Hair Cell Protection in Mammals against the Noise-Induced Cochlear Damage
por: Waqas, Muhammad, et al.
Publicado: (2018)

Nanocarriers for Inner Ear Disease Therapy
por: Xu, Xiaoxiang, et al.
Publicado: (2021)

Role of Inner Ear Macrophages and Autoimmune/Autoinflammatory Mechanisms in the Pathophysiology of Inner Ear Disease
por: Miwa, Toru, et al.
Publicado: (2022)

Inner Ear Therapeutics: An Overview of Middle Ear Delivery
por: Patel, Jaimin, et al.
Publicado: (2019)

Inner ear disturbances related to middle ear inflammation
por: Sone, Michihiko
Publicado: (2017)

Autophagy in the Vertebrate Inner Ear
por: Magariños, Marta, et al.
Publicado: (2017)

Effects of Glucocorticoids on the Inner Ear
por: Takeda, Taizo, et al.
Publicado: (2021)

Editorial: Neuroimmunology of the Inner Ear
por: Perin, Paola, et al.
Publicado: (2021)

Editorial: Autoinflammation of the inner ear
por: Nakanishi, Hiroshi, et al.
Publicado: (2022)

Differential Effects of AAV.BDNF and AAV.Ntf3 in the Deafened Adult Guinea Pig Ear
por: Budenz, Cameron L., et al.
Publicado: (2015)

Co-regulation of the Notch and Wnt signaling pathways promotes supporting cell proliferation and hair cell regeneration in mouse utricles
por: Wu, Jingfang, et al.
Publicado: (2016)

Imaging assessment of profound sensorineural deafness with inner ear anatomical abnormalities
por: Wu, Wei-Jing, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_mum2h64egej1gqp9ems6ajohu6