A novel bispecific antibody platform to direct complement activity for efficient lysis of target cells

Harnessing complement-mediated cytotoxicity by therapeutic antibodies has been limited because of dependency on size and density of antigen, structural constraints resulting from orientation of antibody binding, and blockade of complement activation by inhibitors expressed on target cells. We develo...

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Detalles Bibliográficos
Autores principales: Cruz, Jonathan W., Damko, Ermelinda, Modi, Bhavika, Tu, Naxin, Meagher, Karoline, Voronina, Vera, Gartner, Hans, Ehrlich, George, Rafique, Ashique, Babb, Robert, Aneja, Priya, Potocky, Terra B., D’ Orvilliers, Amanda, Coppi, Alida, E, Sook Yen, Qiu, Haibo, Williams, Courtney M., Bennett, Brandy L., Chen, Gang, Macdonald, Lynn, Olson, William, Lin, John C., Stahl, Neil, Murphy, Andrew J., Kyratsous, Christos A., Prasad, Brinda C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6700171/
https://www.ncbi.nlm.nih.gov/pubmed/31427700
http://dx.doi.org/10.1038/s41598-019-48461-1

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