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A novel bispecific antibody platform to direct complement activity for efficient lysis of target cells
Harnessing complement-mediated cytotoxicity by therapeutic antibodies has been limited because of dependency on size and density of antigen, structural constraints resulting from orientation of antibody binding, and blockade of complement activation by inhibitors expressed on target cells. We develo...
Autores principales: | Cruz, Jonathan W., Damko, Ermelinda, Modi, Bhavika, Tu, Naxin, Meagher, Karoline, Voronina, Vera, Gartner, Hans, Ehrlich, George, Rafique, Ashique, Babb, Robert, Aneja, Priya, Potocky, Terra B., D’ Orvilliers, Amanda, Coppi, Alida, E, Sook Yen, Qiu, Haibo, Williams, Courtney M., Bennett, Brandy L., Chen, Gang, Macdonald, Lynn, Olson, William, Lin, John C., Stahl, Neil, Murphy, Andrew J., Kyratsous, Christos A., Prasad, Brinda C. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6700171/ https://www.ncbi.nlm.nih.gov/pubmed/31427700 http://dx.doi.org/10.1038/s41598-019-48461-1 |
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