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Regulation of gene expression by altered promoter methylation using a CRISPR/Cas9-mediated epigenetic editing system

Despite the increased interest in epigenetic research, its progress has been hampered by a lack of satisfactory tools to control epigenetic factors in specific genomic regions. Until now, many attempts to manipulate DNA methylation have been made using drugs but these drugs are not target-specific a...

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Detalles Bibliográficos
Autores principales: Kang, Jeong Gu, Park, Jin Suk, Ko, Jeong-Heosn, Kim, Yong-Sam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6700181/
https://www.ncbi.nlm.nih.gov/pubmed/31427598
http://dx.doi.org/10.1038/s41598-019-48130-3