Mice with an autosomal dominant Charcot-Marie-Tooth type 2O disease mutation in both dynein alleles display severe moto-sensory phenotypes

Charcot-Marie-Tooth disease (CMT) is the most common peripheral neuromuscular disorder worldwide. The axonal degeneration in CMT causes distal muscle weakness and atrophy, resulting in gait problems and difficulties with basic motor coordination skills. A mutation in the cytoplasmic dynein heavy cha...

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Detalles Bibliográficos
Autores principales: Nandini, Swaran, Conley Calderon, Jami L., Sabblah, Thywill T., Love, Rachal, King, Linda E., King, Stephen J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6700207/
https://www.ncbi.nlm.nih.gov/pubmed/31427617
http://dx.doi.org/10.1038/s41598-019-48431-7

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