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Focused transcranial ultrasound for treatment of neurodegenerative dementia

INTRODUCTION: Preclinical studies support investigation of focused ultrasound for breakdown of cerebral pathologies in neurodegenerative conditions including Alzheimer's disease (AD) and Parkinson's disease (PD). METHODS: A focused transcranial Doppler device with probes (2 MHz, 520 mW/cm(...

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Autores principales: Nicodemus, Natalie Eleanor, Becerra, Sergio, Kuhn, Taylor P., Packham, Hannah R., Duncan, John, Mahdavi, Kennedy, Iovine, Jessica, Kesari, Santosh, Pereles, Scott, Whitney, Mike, Mamoun, Michael, Franc, Daniel, Bystritsky, Alexander, Jordan, Sheldon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6700262/
https://www.ncbi.nlm.nih.gov/pubmed/31440580
http://dx.doi.org/10.1016/j.trci.2019.06.007
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author Nicodemus, Natalie Eleanor
Becerra, Sergio
Kuhn, Taylor P.
Packham, Hannah R.
Duncan, John
Mahdavi, Kennedy
Iovine, Jessica
Kesari, Santosh
Pereles, Scott
Whitney, Mike
Mamoun, Michael
Franc, Daniel
Bystritsky, Alexander
Jordan, Sheldon
author_facet Nicodemus, Natalie Eleanor
Becerra, Sergio
Kuhn, Taylor P.
Packham, Hannah R.
Duncan, John
Mahdavi, Kennedy
Iovine, Jessica
Kesari, Santosh
Pereles, Scott
Whitney, Mike
Mamoun, Michael
Franc, Daniel
Bystritsky, Alexander
Jordan, Sheldon
author_sort Nicodemus, Natalie Eleanor
collection PubMed
description INTRODUCTION: Preclinical studies support investigation of focused ultrasound for breakdown of cerebral pathologies in neurodegenerative conditions including Alzheimer's disease (AD) and Parkinson's disease (PD). METHODS: A focused transcranial Doppler device with probes (2 MHz, 520 mW/cm(2)) affixed bilaterally was used to target the hippocampus (AD) or substantia nigra (PD) with functional magnetic resonance imaging navigation for enhanced plaque removal. A total of 22 patients (n = 11 AD, n = 11 PD) underwent 8 consecutive, weekly, 1-hour treatments wherein sleep was encouraged naturally or pharmacologically. Cognitive and motor functioning assessment was carried out using standardized evaluations at baseline and conclusion. RESULTS: Of all, 62.5% of patients had one or more improved cognitive scores without data incongruence, 87% had stable or improved fine motor scores, and 87.5% had stable or improved gross motor scores. No adverse events were reported. DISCUSSION: The safety of focused transcranial Doppler and possible enhancement in patient functioning were suggested by outcome data.
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spelling pubmed-67002622019-08-22 Focused transcranial ultrasound for treatment of neurodegenerative dementia Nicodemus, Natalie Eleanor Becerra, Sergio Kuhn, Taylor P. Packham, Hannah R. Duncan, John Mahdavi, Kennedy Iovine, Jessica Kesari, Santosh Pereles, Scott Whitney, Mike Mamoun, Michael Franc, Daniel Bystritsky, Alexander Jordan, Sheldon Alzheimers Dement (N Y) Featured Article INTRODUCTION: Preclinical studies support investigation of focused ultrasound for breakdown of cerebral pathologies in neurodegenerative conditions including Alzheimer's disease (AD) and Parkinson's disease (PD). METHODS: A focused transcranial Doppler device with probes (2 MHz, 520 mW/cm(2)) affixed bilaterally was used to target the hippocampus (AD) or substantia nigra (PD) with functional magnetic resonance imaging navigation for enhanced plaque removal. A total of 22 patients (n = 11 AD, n = 11 PD) underwent 8 consecutive, weekly, 1-hour treatments wherein sleep was encouraged naturally or pharmacologically. Cognitive and motor functioning assessment was carried out using standardized evaluations at baseline and conclusion. RESULTS: Of all, 62.5% of patients had one or more improved cognitive scores without data incongruence, 87% had stable or improved fine motor scores, and 87.5% had stable or improved gross motor scores. No adverse events were reported. DISCUSSION: The safety of focused transcranial Doppler and possible enhancement in patient functioning were suggested by outcome data. Elsevier 2019-08-08 /pmc/articles/PMC6700262/ /pubmed/31440580 http://dx.doi.org/10.1016/j.trci.2019.06.007 Text en © 2019 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Featured Article
Nicodemus, Natalie Eleanor
Becerra, Sergio
Kuhn, Taylor P.
Packham, Hannah R.
Duncan, John
Mahdavi, Kennedy
Iovine, Jessica
Kesari, Santosh
Pereles, Scott
Whitney, Mike
Mamoun, Michael
Franc, Daniel
Bystritsky, Alexander
Jordan, Sheldon
Focused transcranial ultrasound for treatment of neurodegenerative dementia
title Focused transcranial ultrasound for treatment of neurodegenerative dementia
title_full Focused transcranial ultrasound for treatment of neurodegenerative dementia
title_fullStr Focused transcranial ultrasound for treatment of neurodegenerative dementia
title_full_unstemmed Focused transcranial ultrasound for treatment of neurodegenerative dementia
title_short Focused transcranial ultrasound for treatment of neurodegenerative dementia
title_sort focused transcranial ultrasound for treatment of neurodegenerative dementia
topic Featured Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6700262/
https://www.ncbi.nlm.nih.gov/pubmed/31440580
http://dx.doi.org/10.1016/j.trci.2019.06.007
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